2011

Datson, N.A., Polman, J.A., de Jonge, R.T., van Boheemen, P.T., van Maanen, E.M., Welten, J., McEwen, B.S., Meiland, H.C., Meijer, O.C. , Specific regulatory motifs predict glucocorticoid responsiveness of hippocampal gene expression, Endocrinology, vol. 152, no. 10, pp. 3749-3757.

de Leeuw-van Weenen, J.E., Auvinen, H.E., Parlevliet, E.T., Coomans, C.P., der Schröder-van Elst, J.P., Meijer, O.C., Pijl, H. , Blocking dopamine D2 receptors by haloperidol curtails the beneficial impact of calorie restriction on the metabolic phenotype of high fat diet induced obese mice, J Neuroendocrinol, vol. 23, no. 2, pp. 158-167.

Schmidt, M.V., Wang, X.D., Meijer, O.C. , Early life stress paradigms in rodents: potential animal models of depression?, Psychopharmacology, vol. 214, no. 1, pp. 131-140.

Llorente, R., Miguel-Blanco, C., Aisa, B., Lachize, S., Borcel, E., Meijer, O.C., Ramirez, M.J., De Kloet, E.R., Viveros, M.P. , Long term sex-dependent psychoneuroendocrine effects of maternal deprivation and juvenile unpredictable stress in rats, J Neuroendocrinol, vol. 23, no. 4, pp. 329-344.

Zalachoras, I, Evers, M.M., van Roon-Mom, W.M., Aartsma-Rus, A.M., Meijer, O.C. , Antisense-mediated RNA targeting: versatile and expedient genetic manipulation in the brain, Front Mol Neurosci, vol. 4, no. 10, pp. 1-12.

2010

Sarabdjitsingh, R.A., Conway-Campbell, B.L., Leggett, J.D., Waite, E.J., Meijer, O.C., de Kloet, E.R., Lightman, S.L. , Stress Responsiveness Varies over the Ultradian Glucocorticoid Cycle in a Brain-Region-Specific Manner, Endocrinology, vol. 151, no. 11, pp. 5369-5379.

Sarabdjitsingh, R.A., Meijer, O.C., de Kloet, E.R. , Specificity of glucocorticoid receptor primary antibodies for analysis of receptor localization patterns in cultured cells and rat hippocampus, Brain Res, vol. 1331, pp. 1-11.

Sarabdjitsingh, R.A., Isenia, S., Polman, J.A., Mijalkovic, J., Lachize, S.B., Datson, N.A., de Kloet, E.R., Meijer, O.C. , Disrupted corticosterone pulsatile patterns attenuate responsiveness to glucocorticoid signaling in rat brain, Endocrinology, vol. 151, no. 3, pp. 1177-1186.

Conway-Campbell, B.L., Sarabdjitsingh, R.A., McKenna, M.A., Pooley, J.R., Kershaw, Y.M., Meijer, O.C., de Kloet, E.R., Lightman, S.L. , Glucocorticoid ultradian rhythmicity directs cyclical gene pulsing of the Clock gene Period 1 in rat hippocampus, J Neuroendocrinol, vol. 22, no. 10, pp. 1093–1100.

Alt, S.R., Turner, J.D., Klok, M.D., Meijer, O.C., Lakke, E.A., de Rijk, R.H., Muller, C.P. , Differential expression of glucocorticoid receptor transcripts in major depressive disorder is not epigenetically programmed, Psychoneuroendocrinology, vol. 35, no. 4, pp. 544-556.

Van Batenburg, M.F., Li, H., Polman, J.A., Lachize, S.B., Datson, N.A., Bussemaker, H.J., Meijer, O.C. , Paired hormone response elements predict caveolin-1 as a glucocorticoid target gene, PLoS One, vol. 5, no. 1, pp. 1-9.

Sarabdjitsingh, R.A., Spiga, F., Oitzl, M.S., Kershaw, Y., Meijer, O.C., Lightman, S.L., De Kloet, E.R. , Recovery from disrupted ultradian glucocorticoid rhythmicity reveals a dissociation between hormonal and behavioral stress responsiveness, J Neuroendocrinol, vol. 22, no. 8, pp. 862-871.

2009

de Kloet, E.R., Fitzsimons, C.P., Datson, N.A., Meijer, O.C., Vreugdenhil, E. , Glucocorticoid signaling and stress-related limbic susceptibility pathway: about receptors, transcription machinery and microRNA, Brain Res, vol. 1293, pp. 129-141.

van Gemert, N.G., Carvalho, D.M., Karst, H., van der Laan, S., Zhang, M., Meijer, O.C., Hell, J.W., Joels, M. , Dissociation between rat hippocampal CA1 and dentate gyrus cells in their response to corticosterone: effects on calcium channel protein and current, Endocrinology, vol. 150, no. 10, pp. 4615-4624.

Lachize, S.B., Apostolakis, E.M., van der Laan, S., Tijssen, A.M., Xu, J., de Kloet, E.R., Meijer, O.C. , Steroid receptor coactivator-1 is necessary for regulation of corticotropin-releasing hormone by chronic stress and glucocorticoids, PNAS, vol. 106, no. 19, pp. 8038-8042.

Vreugdenhil, E., Verissimo, C.S., Mariman, R., Kamphorst, J.T., Barbosa, J.S., Zweers, T., Champagne, D.L., Schouten, T., Meijer, O.C., de Kloet, E.R., Fitzsimons, C.P. , MicroRNA 18 and 124a down-regulate the glucocorticoid receptor: implications for glucocorticoid responsiveness in the brain, Endocrinology, vol. 150, no. 5, pp. 2220-2228.

Sarabdjitsingh, R.A., Meijer, O.C., Schaaf, M.J., de Kloet, E.R. , Subregion-specific differences in translocation patterns of mineralocorticoid and glucocorticoid receptors in rat hippocampus, Brain Res, vol. 1249, pp. 43-53.

van der Laan, S., de Kloet, E.R., Meijer, O.C. , Timing is critical for effective glucocorticoid receptor mediated repression of the cAMP-induced CRH gene, PLoS One, vol. 4, no. 1, pp. 1-6.

Brittijn, S.A., Duivesteijn, S.J., Belmamoune, M., Bertens, L.F., Bitter, W., de Bruijn, J.D., Champagne, D.L., Cuppen, E., Flik, G., Vandenbroucke-Grauls, C.M., Janssen, R.A., de Jong, I.M., de Kloet, E.R., Kros, A., Meijer, A.H., Metz, J.R., van der Sar, A.M., Schaaf, M.J., Schulte-Merker, S., Spaink, H.P., Tak, P.P., Verbeek, F.J., Vervoordeldonk, M.J., Vonk, F.J., Witte, F., Yuan, H., Richardson, M.K. , Zebrafish development and regeneration: new tools for biomedical research, Int J Dev Biol, vol. 53, no. 5-6, pp. 835-850.

2008

van der Laan, S., Sarabdjitsingh, R.A., Van Batenburg, M.F., Lachize, S.B., Li, H., Dijkmans, T.F., Vreugdenhil, E., de Kloet, E.R., Meijer, O.C. , Chromatin immunoprecipitation scanning identifies glucocorticoid receptor binding regions in the proximal promoter of a ubiquitously expressed glucocorticoid target gene in brain, J Neurochem, vol. 106, no. 6, pp. 2515-2523.

Liebmann, L., Karst, H., Sidiropoulou, K., Van Gemert, N., Meijer, O.C., Poirazi, P., Joels, M. , Differential effects of corticosterone on the slow afterhyperpolarization in the basolateral amygdala and CA1 region: Possible role of calcium channel subunits, Journal of Neurophysiology, vol. 99, no. 2, pp. 958-968.

van der Laan, S., Lachize, S.B., Vreugdenhil, E., de Kloet, E.R., Meijer, O.C. , Nuclear receptor coregulators differentially modulate induction and glucocorticoid receptor-mediated repression of the corticotropin-releasing hormone gene, Endocrinology, vol. 149, no. 2, pp. 725-732.

Datson, N.A., Morsink, M.C., Meijer, O.C., de Kloet, E.R. , Central corticosteroid actions: Search for gene targets, Eur J Pharmacol, vol. 583, no. 2-3, pp. 272-289.

de Kloet, E.R., Han, F., Meijer, O.C. , From the stalk to down under about brain glucocorticoid receptors, stress and development, Neurochem Res, vol. 33, no. 4, pp. 637-642.

Meijer, O.C., De Kloet, E.R. , Coregulators in CNS Function and Disease, Nuclear Receptor Coregulators and Human Diseases: World Scientific Publishing, pp. 383-408.

Schaaf, M.J., Champagne, D.L., van Laanen, I, van Wijk, D.C., Meijer, A.H., Meijer, O.C., Spaink, H.P., Richardson, M.K. , Discovery of a functional glucocorticoid receptor beta-isoform in zebrafish, Endocrinology, vol. 149, no. 4, pp. 1591-1599.

Topic, B., Oitzl, M.S., Meijer, O.C., Huston, J.P., Silva, M.A.D. , Differential Susceptibility to Extinction-Induced Despair and Age-Dependent Alterations in the Hypothalamic-Pituitary-Adrenal Axis and Neurochemical Parameters, Neuropsychobiology, vol. 58, no. 3-4, pp. 138-153.

Abildayeva, K., Berbee, J.F., Blokland, A., Jansen, P.J., Hoek, F.J., Meijer, O.C., Lutjohann, D., Gautier, T., Pillot, T., De Vente, J., Havekes, L.M., Ramaekers, F.C., Kuipers, F., Rensen, P.C., Mulder, M. , Human apolipoprotein C-I expression in mice impairs learning and memory functions, J Lipid Res, vol. 49, no. 4, pp. 856-869.

van der Laan, S., Meijer, O.C. , Pharmacology of glucocorticoids: Beyond receptors, Eur J Pharmacol, vol. 585, no. 2-3, pp. 483-491.

De Bosscher, K., Van Craenenbroeck, K., Meijer, O.C., Haegeman, G. , Selective transrepression versus transactivation mechanisms by glucocorticoid receptor modulators in stress and immune systems, Eur J Pharmacol, vol. 583, no. 2-3, pp. 290-302.

2007

Schmidt, M.V., Oitzl, M.S., Steenbergen, P.J., Lachize, S.B., Wurst, W., Muller, M.B., de Kloet, E.R., Meijer, O.C. , Ontogeny of steroid receptor coactivators in the hippocampus and their role in regulating postnatal HPA axis function, Brain Res, vol. 1174, pp. 1-6.

de Kloet, E.R., De Rijk, R.H., Meijer, O.C. , Therapy Insight: is there an imbalanced response of mineralocorticoid and glucocorticoid receptors in depression?, Nat Clin Pract Endocrinol Metab, vol. 3, no. 2, pp. 168-179.

Meijer, O.C., De Kloet, E.R., McEwen, B.S. , Corticosteroid Receptors, Encyclopedia of Stress, vol. 2nd, New York, Elsevier / Academic Press, pp. 594-605.

Sonneveld, E., Jonas, A., Meijer, O.C., Brouwer, A., van der Burg, B. , Glucocorticoid-Enhanced Expression of Dioxin Target Genes through Regulation of the Rat Aryl Hydrocarbon Receptor, Toxicol Sci, vol. 99, no. 2, pp. 455-469.

Kap, Y.S., Hoozemans, J.J., Bodewes, A.J., Zwart, R., Meijer, O.C., Baas, F., Scheper, W. , Pin1 levels are downregulated during ER stress in human neuroblastoma cells, Neurogenetics, vol. 8, no. 1, pp. 21-27.

2006

van Gemert, N.G., Meijer, O.C., Morsink, M.C., Joels, M. , Effect of brief corticosterone administration on SGK1 and RGS4 mRNA expression in rat hippocampus, Stress, vol. 9, no. 3, pp. 165-170.

van Leeuwen, N., Wust, S., Meijer, O.C., de Kloet, E.R., Zitman, F.G., de Rijk, R.H. , The role of single nucleotide polymorphisms (SNPs) in the mineralocorticoid receptor (MR) in stress response and psychopathology, American Journal of Medical Genetics Part B-Neuropsychiatric Genetics, vol. 141B, no. 7, pp. 752-752.

Morsink, M.C., Joels, M., Sarabdjitsingh, R.A., Meijer, O.C., De Kloet, E.R., Datson, N.A. , The dynamic pattern of glucocorticoid receptor-mediated transcriptional responses in neuronal PC12 cells, J Neurochem, vol. 99, no. 4, pp. 1282-1298.

van Gemert, N.G., van Riel, E., Meijer, O.C., Fehr, S., Schachner, M., Joels, M. , No effect of prolonged corticosterone over-exposure on NCAM, SGK1, and RGS4 mRNA expression in rat hippocampus, Brain Res, vol. 1093, no. 1, pp. 161-166.

Tjin, E.P., Groen, R.W., Vogelzang, I, Derksen, P.W., Klok, M.D., Meijer, H.P., van Eeden, S., Pals, S.T., Spaargaren, M. , Functional analysis of HGF/MET signaling and aberrant HGF-activator expression in diffuse large B-cell lymphoma, Blood, vol. 107, no. 2, pp. 760-8.

De Rijk, R.H., Wust, S., Meijer, O.C., Zennaro, M.C., Federenko, I.S., Hellhammer, D.H., Giacchetti, G., Vreugdenhil, E., Zitman, F.G., de Kloet, E.R. , A common polymorphism in the mineralocorticoid receptor modulates stress responsiveness, J Clin Endocrinol Metab, vol. 91, no. 12, pp. 5083-5089.

Gabor, K., Verissimo, C.S., Cyran, B.C., Ter Horst, P., Meijer, N.P., Smidt, H., de Vos, W.M., van der Oost, J. , Characterization of CprK1, a CRP/FNR-type transcriptional regulator of halorespiration from Desulfitobacterium hafniense, Journal of Bacteriology, vol. 188, no. 7, pp. 2604-2613.

Wright, R.L., Lightner, E.N., Harman, J.S., Meijer, O.C., Conrad, C.D. , Attenuating corticosterone levels on the day of memory assessment prevents chronic stress-induced impairments in spatial memory, Eur J Neurosci, vol. 24, no. 2, pp. 595-605.

Meijer, O.C., van der Laan, S., Lachize, S.B., Steenbergen, P.J., de Kloet, E.R. , Steroid receptor coregulator diversity: what can it mean for the stressed brain?, Neuroscience, vol. 138, no. 3, pp. 891-899.

Meijer, O.C. , Understanding stress through the genome, Stress, vol. 9, no. 2, pp. 61-67.

2005

van der Laan, S., Lachize, S.B., Schouten, T.G., Vreugdenhil, E., de Kloet, E.R., Meijer, O.C. , Neuroanatomical distribution and colocalisation of nuclear receptor corepressor (N-CoR) and silencing mediator of retinoid and thyroid receptors (SMRT) in rat brain, Brain Res, vol. 1059, no. 2, pp. 113-121.

Meijer, O.C., Kalkhoven, E., van der Laan, S., Steenbergen, P.J., Houtman, S.H., Dijkmans, T.F., Pearce, D., de Kloet, E.R. , Steroid receptor coactivator-1 splice variants differentially affect corticosteroid receptor signaling, Endocrinology, vol. 146, no. 3, pp. 1438-1448.

Karssen, A.M., Meijer, O.C., Berry, A., Sanjuan Pinol, R., de Kloet, E.R. , Low doses of dexamethasone can produce a hypocorticosteroid state in the brain, Endocrinology, vol. 146, no. 12, pp. 5587-5595.

Dalm, S., Enthoven, L., Meijer, O.C., van der Mark, M.H., Karssen, A.M., de Kloet, E.R., Oitzl, M.S. , Age-related changes in hypothalamic-pituitary-adrenal axis activity of male C57BL/6J mice, Neuroendocrinology, vol. 81, no. 6, pp. 372-380.

Wust, S., de Rijk, R.H., Meijer, O.C., Federenko, I, Vreugdenhil, E., de Punder, K., Hellhammer, D., De Kloet, E.R. , A common mineralocorticoid receptor gene variant is associated with cortisol and heart rate response to psychosocial stress, J Psychophysiology, vol. 19, no. 2, pp. 154-155.

De Kloet, E.R., Schmidt, M.V., Meijer, O.C. , Corticosteroid receptors and HPA axis regulation, Handbook of stress and the brain, vol. 1, Amsterdam, Elsevier, pp. 265-295.

Karssen, A.M., Meijer, O.C., de Kloet, E.R. , Corticosteroids and the blood-brain barrier, Handbook of stress and the brain, vol. 1, Amsterdam, Elsevier, pp. 329-341.

Meijer, O.C., Topic, B., Steenbergen, P.J., Jocham, G., Huston, J.P., Oitzl, M.S. , Correlations between hypothalamus-pituitary-adrenal axis parameters depend on age and learning capacity, Endocrinology, vol. 146, no. 3, pp. 1372-1381.

2004

Datson, N.A., Meijer, L., Steenbergen, P.J., Morsink, M.C., van der Laan, S., Meijer, O.C., de Kloet, E.R. , Expression profiling in laser-microdissected hippocampal subregions in rat brain reveals large subregion-specific differences in expression, Eur J Neurosci, vol. 20, no. 10, pp. 2541-2554.

van Riel, E., van Gemert, N.G., Meijer, O.C., Joels, M. , Effect of early life stress on serotonin responses in the hippocampus of young adult rats, Synapse, vol. 53, no. 1, pp. 11-19.

Karssen, A.M., Meijer, O.C., Pons, D., De Kloet, E.R. , Localization of mRNA expression of P-glycoprotein at the blood-brain barrier and in the hippocampus, Ann N Y Acad Sci, vol. 1032, pp. 308-311.

Derksen, P.W., Tjin, E., Meijer, H.P., Klok, M.D., MacGillavry, H.D., van Oers, M.H., Lokhorst, H.M., Bloem, A.C., Clevers, H., Nusse, R., van der Neut, R., Spaargaren, M., Pals, S.T. , Illegitimate WNT signaling promotes proliferation of multiple myeloma cells, PNAS, vol. 101, no. 16, pp. 6122-7.

De Kloet, E.R., Karssen, A.M., Meijer, O.C., Oitzl, M.S. , Central effects of glucocorticoid antagonists: Preclinical studies, Biol Psychiatry, vol. 55, no. 8, Suppl-1, pp. 190S-191S.

2003

Spaargaren, M., Beuling, E.A., Rurup, M.L., Meijer, H.P., Klok, M.D., Middendorp, S., Hendriks, R.W., Pals, S.T. , The B cell antigen receptor controls integrin activity through Btk and PLCgamma2, J Exp Med, vol. 198, no. 10, pp. 1539-50.

Veenema, A.H., Meijer, O.C., de Kloet, E.R., Koolhaas, J.M. , Genetic selection for coping style predicts stressor susceptibility, J Neuroendocrinol, vol. 15, no. 3, pp. 256-67.

Meijer, O.C., Karssen, A.M., de Kloet, E.R. , Cell- and tIssue-specific effects of corticosteroids in relation to glucocorticoid resistance: examples from the brain, J Endocrinol, vol. 178, no. 1, pp. 13-18.

Veenema, A.H., Meijer, O.C., de Kloet, E.R., Koolhaas, J.M., Bohus, B.G. , Differences in basal and stress-induced HPA regulation of wild house mice selected for high and low aggression, Horm Behav, vol. 43, no. 1, pp. 197-204.

van Riel, E., Meijer, O.C., Steenbergen, P.J., Joels, M. , Chronic unpredictable stress causes attenuation of serotonin responses in cornu ammonis 1 pyramidal neurons, Neuroscience, vol. 120, no. 3, pp. 649-658.

Adams, M., Meijer, O.C., Wang, J., Bhargava, A., Pearce, D. , Homodimerization of the glucocorticoid receptor is not essential for response element binding: activation of the phenylethanolamine N-methyltransferase gene by dimerization-defective mutants, Mol Endocrinol, vol. 17, no. 12, pp. 2583-2592.

2002

Karssen, A.M., Meijer, O.C., van der Sandt, I.C., De Boer, A.G., De Lange, E.C., De Kloet, E.R. , The role of the efflux transporter P-glycoprotein in brain penetration of prednisolone, J Endocrinol, vol. 175, no. 1, pp. 251-260.

Meijer, O.C. , Coregulator proteins and corticosteroid action in the brain, J Neuroendocrinol, vol. 14, no. 6, pp. 499-505.

van Riel, E., Meijer, O.C., Veenema, A.H., Joels, M. , Hippocampal serotonin responses in short and long attack latency mice, J Neuroendocrinol, vol. 14, no. 3, pp. 234-239.

2001

Karssen, A.M., Meijer, O.C., van der Sandt, I.C., Lucassen, P.J., de Lange, E.C., de Boer, A.G., de Kloet, E.R. , Multidrug resistance P-glycoprotein hampers the access of cortisol but not of corticosterone to mouse and human brain, Endocrinology, vol. 142, no. 6, pp. 2686-2694.

de Rijk, R.H., Meijer, O.C., De Kloet, E.R. , Brain corticosteroid receptors: targets for treatment of depression, Physical Consequences of Depression, Petersfield, UK, Wrightson Biomedical Pub, pp. 23-52.

2000

Sibug, R.M., Compaan, J.C., Meijer, O.C., Van der Gugten, J., Olivier, B., De Kloet, E.R. , Effects of flesinoxan on corticosteroid receptor expression in the rat hippocampus, Eur J Pharmacol, vol. 404, no. 1-2, pp. 111-9.

Meijer, O.C., Steenbergen, P.J., De Kloet, E.R. , Differential expression and regional distribution of steroid receptor coactivators SRC-1 and SRC-2 in brain and pituitary, Endocrinology, vol. 141, no. 6, pp. 2192-2199.

de Kloet, E.R., Meijer, O.C., Vreugdenhil, E., Joels, M. , The Yin and Yang of nuclear receptors: symposium on nuclear receptors in brain, Oegstgeest, The Netherlands, 13-14 April 2000, Trends Endocrinol Metab, vol. 11, no. 6, pp. 245-8.

de Kloet, E.R., Van Acker, S.A., Sibug, R.M., Oitzl, M.S., Meijer, O.C., Rahmouni, K., de Jong, W. , Brain mineralocorticoid receptors and centrally regulated functions, Kidney Int, vol. 57, no. 4, pp. 1329-36.

Bhatnagar, S., Viau, V., Chu, A., Soriano, L., Meijer, O.C., Dallman, M.F. , A cholecystokinin-mediated pathway to the paraventricular thalamus is recruited in chronically stressed rats and regulates hypothalamic-pituitary-adrenal function, J Neurosci, vol. 20, no. 14, pp. 5564-5573.

Meijer, O.C., De Kloet, E.R., McEwen, B.S. , Corticosteroid Receptors, Encyclopedia of Stress, vol. 1st, New York, Academic Press, pp. 557-569.

Bhargava, A., Meijer, O.C., Dallman, M.F., Pearce, D. , Plasma membrane calcium pump isoform 1 gene expression is repressed by corticosterone and stress in rat hippocampus, J Neurosci, vol. 20, no. 9, pp. 3129-3138.

Pearce, D., Verrey, F., Chen, S.Y., Mastroberardino, L., Meijer, O.C., Wang, J., Bhargava, A. , Role of SGK in mineralocorticoid-regulated sodium transport, Kidney Int., vol. 57, no. 4, pp. 1283-1289.

Wissink, S., Meijer, O.C., Pearce, D., van der Burg, B., van der Saag, P.T. , Regulation of the rat serotonin-1A receptor gene by corticosteroids, J Biol Chem, vol. 275, no. 2, pp. 1321-1326.

Meijer, O.C., Williamson, A., Dallman, M.F., Pearce, D. , Transcriptional repression of the 5-HT1A receptor promoter by corticosterone via mineralocorticoid receptors depends on the cellular context, J Neuroendocrinol, vol. 12, no. 3, pp. 245-254.

1999

Chen, S.Y., Bhargava, A., Mastroberardino, L., Meijer, O.C., Wang, J., Buse, P., Firestone, G.L., Verrey, F., Pearce, D. , Epithelial sodium channel regulated by aldosterone-induced protein sgk, PNAS, vol. 96, no. 5, pp. 2514-2519.

Dallman, M.F., Akana, S.F., Bhatnagar, S., Bell, M.E., Choi, S., Chu, A., Horsley, C., Levin, N., Meijer, O.C., Soriano, L.R., Strack, A.M., Viau, V. , Starvation: early signals, sensors, and sequelae, Endocrinology, vol. 140, no. 9, pp. 4015-4023.

1998

Meijer, O.C., Kortekaas, R., Oitzl, M.S., de Kloet, E.R. , Acute rise in corticosterone facilitates 5-HT(1A) receptor-mediated behavioural responses, Eur J Pharmacol, vol. 351, no. 1, pp. 7-14.

Sibug, R.M., Compaan, J.C., Meijer, O.C., Van der Gugten, J., Olivier, B., De Kloet, E.R. , Flesinoxan treatment reduces 5-HT1A receptor mRNA in the dentate gyrus independently of high plasma corticosterone levels, Eur J Pharmacol, vol. 353, no. 2-3, pp. 207-14.

Meijer, O.C., de Lange, E.C., Breimer, D.D., de Boer, A.G., Workel, J.O., de Kloet, E.R. , Penetration of dexamethasone into brain glucocorticoid targets is enhanced in mdr1A P-glycoprotein knockout mice, Endocrinology, vol. 139, no. 4, pp. 1789-1793.

Meijer, O.C., de Kloet, E.R. , Corticosterone and serotonergic neurotransmission in the hippocampus: functional implications of central corticosteroid receptor diversity, Crit Rev Neurobiol, vol. 12, no. 1-2, pp. 1-20.

1997

Meijer, O.C., Van Oosten, R.V., De Kloet, E.R. , Elevated basal trough levels of corticosterone suppress hippocampal 5-hydroxytryptamine(1A) receptor expression in adrenally intact rats: implication for the pathogenesis of depression, Neuroscience, vol. 80, no. 2, pp. 419-426.

Meijer, O.C., Cole, T.J., Schmid, W., Schutz, G., Joels, M., De Kloet, E.R. , Regulation of hippocampal 5-HT1A receptor mRNA and binding in transgenic mice with a targeted disruption of the glucocorticoid receptor, Brain Res Mol Brain Res, vol. 46, no. 1-2, pp. 290-296.

1996

Vreugdenhil, E., de Jong, J., Schaaf, M.J., Meijer, O.C., Busscher, J., Vuijst, C., de Kloet, E.R. , Molecular dissection of corticosteroid action in the rat hippocampus. Application of the differential display techniques, J Mol Neurosci, vol. 7, no. 2, pp. 135-146.

Korte, S.M., Meijer, O.C., de Kloet, E.R., Buwalda, B., Keijser, J., Sluyter, F., van Oortmerssen, G., Bohus, B. , Enhanced 5-HT1A receptor expression in forebrain regions of aggressive house mice, Brain Res, vol. 736, no. 1-2, pp. 338-343.

Hesen, W., Karst, H., Meijer, O.C., Cole, T.J., Schmid, W., de Kloet, E.R., Schutz, G., Joels, M. , Hippocampal cell responses in mice with a targeted glucocorticoid receptor gene disruption, J Neurosci, vol. 16, no. 21, pp. 6766-6774.

Meijer, O.C. , Corticosterone and Hippocampal 5-HT 1A Receptors: Functional implications of central corticosteroid receptor diversity, , vol. PhD, Leiden, Leiden University.

1995

Korte, S.M., Buwalda, B., Meijer, O.C., De Kloet, E.R., Bohus, B. , Socially defeated male rats display a blunted adrenocortical response to a low dose of 8-OH-DPAT, Eur J Pharmacol, vol. 272, no. 1, pp. 45-50.

Meijer, O.C., de Kloet, E.R. , A role for the mineralocorticoid receptor in a rapid and transient suppression of hippocampal 5-HT1A receptor mRNA by corticosterone, J Neuroendocrinol, vol. 7, no. 8, pp. 653-657.

1994

Meijer, O.C., Oitzl, M.S., de Kloet, E.R. , Adrenalectomy leads to a different responsiveness to 8-OH-DPAT in a water-maze learning task, Ann N Y Acad Sci, vol. 746, pp. 408-10.

Meijer, O.C., de Kloet, E.R. , Corticosterone suppresses the expression of 5-HT1A receptor mRNA in rat dentate gyrus, Eur J Pharmacol, vol. 266, no. 3, pp. 255-261.

1993

Adan, R.A.H., Meijer, O.C., Burbach, J.P.H. , The effect of lesions of neural inputs to hypothalamic magnocellular neurons on the expression of vasopressin and oxytocin genes, Neuroscience Research Communications, vol. 13, no. 2, pp. 115-123.

de Kloet, E.R., Sutanto, W., van den Berg, D.T., Carey, M.P., van Haarst, A.D., Hornsby, C.D., Meijer, O.C., Rots, N.Y., Oitzl, M.S. , Brain mineralocorticoid receptor diversity: functional implications, J Steroid Biochem Mol Biol, vol. 47, no. 1-6, pp. 183-190.

1992

Burbach, J.P., Meijer, O.C. , The structure of neuropeptide receptors, Eur J Pharmacol, vol. 227, no. 1, pp. 1-18.

1990

Driessen, O.M., Treuren, L., Moolenaar, A., Meijer, J.W.A., Verheijen, P. , In vivo distribution of hydrocortisone over whole blood: a novel method for the extraction of erythrocytes, Methods Find Exp Clin Pharmacol, vol. 12, no. 2, pp. 119-126.

1989

Driessen, O.M., Treuren, L., Meijer, J.W.A. , Distribution of drugs over whole blood: I. The transport function of whole blood for valproate, Ther Drug Monit, vol. 11, no. 4, pp. 384-389.

Driessen, O.M., Treuren, L., Meijer, J.W.A., Hermans, J. , Distribution of drugs over whole blood: II. The transport function of whole blood for phenytoin, Ther Drug Monit, vol. 11, no. 4, pp. 390-400.

Driessen, O.M., Treuren, L., Moolenaar, A.J., Meijer, J.W.A. , Distribution of drugs over whole blood: III. The transport function of whole blood for hydrocortisone, Ther Drug Monit, vol. 11, no. 4, pp. 401-407.

1984

Straathof, D.J., Driessen, O.M., Meijer, J.W.A., Van Rees, H., Vermeij, P., Vermeij, T.A.C. , Influence of Intralipid infusion on the elimination of phenytoin, Arch Int Pharmacodyn Ther, vol. 267, no. 2, pp. 180-186.

1978

Goedhart, D.M., Driessen, O.M., Meijer, J.W. , The extraction of antiepileptic drugs. Model study on partition coefficients, Arzneimittelforschung, vol. 28, no. 1, pp. 19-21.

1975

Meinardi, H., Van Der Kleijn, E., Meijer, J.W., Van Rees, H. , Absorption and distribution of antiepileptic drugs, Epilepsia, vol. 16, no. 2, pp. 353-365.

Onno currently supervises the following students:

• Ioannis Zalachoras

Research Interest: Glucocorticoids and Adaptation to Stress

My field of interest is the biology of stress, in particular the effects of stress-related steroid hormones, glucocorticoids. Stress responses are essential for survival of the organism, yet chronic stress is a strong risk factor for pathology, including psychiatric disorders. One of the main coordinating factors in stress is constituted by the glucocorticoids. How does the hormonal component exert its coordinate beneficial action in physiology and how does overexposure put us at risk for (psycho)pathology?

My objective is to elucidate the effects of glucocorticoid hormones under different conditions related to health and disease. My approach is to study cellular effects of these hormones in different brain areas, with emphasis on transcription, and to relate these findings to the physiology of stress responsiveness. The two main perspectives are 1) the understanding of adaptative mechanisms in stress through analysis of the responsiveness to glucocorticoids, and 2) the translation of different molecular modes of action of glucocorticoids into predictions of novel drugs with a more specific action.