Ron de Kloet | Medical Pharmacology

Ron de Kloet, Prof. Dr.

Position:

Professor

Telephone number: +31 (0)71 527 6210/90
E-mail address: e.kloet@lacdr.leidenuniv.nl
Faculty/Unit: Faculty of Science, Leiden/Amsterdam Center for Drug Research, Medical Pharmacology
Office address: Gorlaeus Laboratories
Einsteinweg 55
2333 CC Leiden
roomnumber HB-902

Biography

My inspiration

‘Stress is the spice of life’ said Hans Selye the father of the stress concept more than half a century ago. And he is right of course: studying the biology of stress touches all aspects of life from health and happiness to disease and misery. The key to the understanding of stress biology is the stress hormone. I want to find out how such hormones can change from protective into harmful signals. What is the cause and what are the consequences? Today such questions are addressed with gene technology to identify vulnerable phenotypes and with in depth analysis of brain functioning under stress to understand why one individual stays healthy and the other gets ill under similar adverse conditions.

Titles of major publications:

* (2004) Van Praag HM, De Kloet ER, van Os J., Stress, the Brain and Depression, Cambridge University Press.

* (2001) Oitzl MS, Reichardt HM, Joëls M, De Kloet ER, "Point mutation in the mouse glucocorticoid receptor preventing DNA binding impairs spatial memory", Proc Natl Acad Sci 98; 12790-12795.

* (1999) De Kloet ER, Oitzl MS, Joëls M, "Stress and cognition: are corticosteroids good or bad guys?" Trends in Neuroscience: 22; 422-426.

* (1989) Joëls M, De Kloet ER, "Effects of glucocorticoids and norepinephrine on excitability in the hippocampus", Science: 245; 1502-1505.

Links:

http://www.rondekloet.nl

http://www.isihighlycited.com

2011

Klok, M.D., Vreeburg, S.A., Penninx, B.W., Zitman, F.G., de Kloet, E.R., De Rijk, R.H. , Common functional mineralocorticoid receptor polymorphisms modulate the cortisol awakening response: Interaction with SSRIs, Psychoneuroendocrinology, vol. 36, no. 4, pp. 484-494.

Sarabdjitsingh, R.A., Joels, M., de Kloet, E.R. , Glucocorticoid pulsatility and rapid corticosteroid actions in the central stress response, Physiol Behav.

Ter Horst, J.P., de Kloet, E.R., Schachinger, H., Oitzl, M.S. , Relevance of Stress and Female Sex Hormones for Emotion and Cognition, Cell Mol Neurobiol, pp. 1-11.

van Leeuwen, N., Bellingrath, S., de Kloet, E.R., Zitman, F.G., De Rijk, R.H., Kudielka, B.M., Wust, S. , Human mineralocorticoid receptor (MR) gene haplotypes modulate MR expression and transactivation: Implication for the stress response, Psychoneuroendocrinology, vol. 36, no. 5, pp. 699-709.

Datson, N.A., Speksnijder, N., de Jong, I.E.M., Steenbergen, P.J., Vielsted Christensen, K., Potempa, K., Torleif Pedersen, J., Egebjerg, J., Kallunki, P., Nielsen, E.B., de Kloet, E.R., Didriksen, M. , Hippocampal CA1 region shows differential regulation of gene expression in mice displaying extremes in behavioral sensitization to amphetamine: relevance for psychosis susceptibility?, Psychopharmacology, vol. 217, no. 4, pp. 525-538.

Daskalakis, N.P., Claessens, S.E., Laboyrie, J.J., Enthoven, L., Oitzl, M.S., Champagne, D.L., de Kloet, E.R. , The newborn rat's stress system readily habituates to repeated and prolonged maternal separation, while continuing to respond to stressors in context dependent fashion, Horm Behav, vol. 60, no. 2, pp. 165-176.

Daskalakis, N.P., Martens, G.J., Cools, A.R., de Kloet, E.R. , Schizophrenia endophenotypes and stress hyper-reactivity co-precipitate following adverse life events in genetically susceptible rats, European Neuropsychopharmacology, vol. 21, pp. S85-S86.

Groeneweg, F.L., Karst, H., de Kloet, E.R., Joels, M. , Mineralocorticoid and glucocorticoid receptors at the neuronal membrane, regulators of nongenomic corticosteroid signalling, Mol Cell Endocrinol.

Groeneweg, F.L., Karst, H., de Kloet, E.R., Joels, M. , Rapid non-genomic effects of corticosteroids and their role in the central stress response, J Endocrinol, vol. 209, pp. 153-167.

Klok, M.D., Alt, S.R., Irurzun Lafitte, A.J., Turner, J.D., Lakke, E.A., Huitinga, I, Muller, C.P., Zitman, F.G., de Kloet, E.R., De Rijk, R.H. , Decreased expression of mineralocorticoid receptor mRNA and its splice variants in postmortem brain regions of patients with major depressive disorder, J Psychiatr Res, vol. 45, no. 7, pp. 871-878.

Schenk, G.J., Vreugdenhil, E., Hubens, C.J., Veldhuisen, B., de Kloet, E.R., Oitzl, M.S. , Hippocampal CARP over-expression solidifies consolidation of contextual fear memories, Physiol Behav, vol. 102, no. 3-4, pp. 323-331.

Claessens, S.E., Daskalakis, N.P., van der Veen, R., Oitzl, M.S., de Kloet, E.R., Champagne, D.L. , Development of individual differences in stress responsiveness: an overview of factors mediating the outcome of early life experiences, Psychopharmacology, vol. 214, no. 1, pp. 141-154.

Llorente, R., Miguel-Blanco, C., Aisa, B., Lachize, S., Borcel, E., Meijer, O.C., Ramirez, M.J., De Kloet, E.R., Viveros, M.P. , Long term sex-dependent psychoneuroendocrine effects of maternal deprivation and juvenile unpredictable stress in rats, J Neuroendocrinol, vol. 23, no. 4, pp. 329-344.

De Rijk, R.H., de Kloet, E.R., Zitman, F.G., van Leeuwen, N. , Mineralocorticoid Receptor Gene Variants as Determinants of HPA Axis Regulation and Behavior, Endocr Dev, vol. 20, pp. 137-148.

2010

Sarabdjitsingh, R.A., Conway-Campbell, B.L., Leggett, J.D., Waite, E.J., Meijer, O.C., de Kloet, E.R., Lightman, S.L. , Stress Responsiveness Varies over the Ultradian Glucocorticoid Cycle in a Brain-Region-Specific Manner, Endocrinology, vol. 151, no. 11, pp. 5369-5379.

Schenk, G.J., Werkman, T., Wadman, W., Veldhuisen, B., Dijkmans, T.F., Blaas, E., Kegel, L., de Kloet, E.R., Vreugdenhil, E. , Over-expression of the DCLK gene transcript CARP decreases CA3/CA1 network excitability, Brain Res, vol. 1352, pp. 21-34.

Luo, L., Rodriguez, E., Jerbi, K., Lachaux, J.P., Martinerie, J., Corbetta, M., Shulman, G.L., Piomelli, D., Turrigiano, G.G., Nelson, S.B., Joels, M., de Kloet, E.R., Holsboer, F., Amodio, D.M., Frith, C.D., Block, M.L., Zecca, L., Hong, J.S., Dantzer, R., Kelley, K.W., Bud Craig, A.D. , Ten years of Nature Reviews Neuroscience: insights from the highly cited, Nat Rev Neurosci, vol. 11, no. 10, pp. 718-726.

Schwabe, L., Schachinger, H., de Kloet, E.R., Oitzl, M.S. , Stress impairs spatial but not early stimulus-response learning, Behav Brain Res, vol. 213, no. 1, pp. 50-55.

van Leeuwen, N., Caprio, M., Blaya, C., Fumeron, F., Sartorato, P., Ronconi, V., Giacchetti, G., Mantero, F., Fernandes-Rosa, F.L., Simian, C., Peyrard, S., Zitman, F.G., Penninx, B.W., de Kloet, E.R., Azizi, M., Jeunemaitre, X., De Rijk, R.H., Zennaro, M.C. , The functional c.-2G>C variant of the mineralocorticoid receptor modulates blood pressure, renin, and aldosterone levels, Hypertension, vol. 56, no. 5, pp. 995-1002.

Sarabdjitsingh, R.A., Meijer, O.C., de Kloet, E.R. , Specificity of glucocorticoid receptor primary antibodies for analysis of receptor localization patterns in cultured cells and rat hippocampus, Brain Res, vol. 1331, pp. 1-11.

Oitzl, M.S., Champagne, D.L., van der Veen, R., de Kloet, E.R. , Brain development under stress: hypotheses of glucocorticoid actions revisited, Neurosci Biobehav Rev, vol. 34, no. 6, pp. 853-866.

Berry, A., Carnevale, D., Giorgio, M., Pelicci, P.G., de Kloet, E.R., Alleva, E., Minghetti, L., Cirulli, F. , Greater resistance to inflammation at adulthood could contribute to extended life span of p66(Shc-/-) mice, Exp Gerontol, vol. 45, no. 5, pp. 343-350.

Sarabdjitsingh, R.A., Isenia, S., Polman, J.A., Mijalkovic, J., Lachize, S.B., Datson, N.A., de Kloet, E.R., Meijer, O.C. , Disrupted corticosterone pulsatile patterns attenuate responsiveness to glucocorticoid signaling in rat brain, Endocrinology, vol. 151, no. 3, pp. 1177-1186.

Conway-Campbell, B.L., Sarabdjitsingh, R.A., McKenna, M.A., Pooley, J.R., Kershaw, Y.M., Meijer, O.C., de Kloet, E.R., Lightman, S.L. , Glucocorticoid ultradian rhythmicity directs cyclical gene pulsing of the Clock gene Period 1 in rat hippocampus, J Neuroendocrinol, vol. 22, no. 10, pp. 1093–1100.

Schwabe, L., Schachinger, H., de Kloet, E.R., Oitzl, M.S. , Corticosteroids operate as a switch between memory systems, J Cogn Neurosci, vol. 22, no. 7, pp. 1362-1372.

de Kloet, E.R. , From vasotocin to stress and cognition, Eur J Pharmacol, vol. 626, no. 1, pp. 18-26.

Champagne, D.L., Hoefnagels, C.C., de Kloet, E.R., Richardson, M.K. , Translating rodent behavioral repertoire to zebrafish (Danio rerio): relevance for stress research, Behav Brain Res, vol. 214, no. 2, pp. 332-342.

Datson, N.A., Speksnijder, N., Mayer, J.L., Steenbergen, P.J., Korobko, O., Goeman, J., de Kloet, E.R., Joels, M., Lucassen, P.J. , The transcriptional response to chronic stress and glucocorticoid receptor blockade in the hippocampal dentate gyrus, Hippocampus, pp. 1-13.

Daskalakis, N.P., Fung, W.L., Schnorr, S., Meelis, W., Oitzl, M.S., de Kloet, E.R. , The three hit hypothesis of schizophrenia tested in genetically selected rats exposed to early life experience and adolescent psycho-social stressor, Int J Dev Neurosci, vol. 28, no. 8, pp. 698-698.

Schenk, G.J., Veldhuisen, B., Wedemeier, O., McGown, C.C., Schouten, T.G., Oitzl, M.S., de Kloet, E.R., Vreugdenhil, E. , Over-expression of deltaC-DCLK-short in mouse brain results in a more anxious behavioral phenotype, Physiol Behav, vol. 101, no. 4, pp. 541-548.

van Leeuwen, N., Kumsta, R., Entringer, S., de Kloet, E.R., Zitman, F.G., De Rijk, R.H., Wust, S. , Functional mineralocorticoid receptor (MR) gene variation influences the cortisol awakening response after dexamethasone, Psychoneuroendocrinology, vol. 35, no. 3, pp. 339-349.

Enthoven, L., Schmidt, M.V., Cheung, Y.H., van der Mark, M.H., de Kloet, E.R., Oitzl, M.S. , Ontogeny of the HPA axis of the CD1 mouse following 24 h maternal deprivation at pnd 3, Int J Dev Neurosci, vol. 28, no. 2, pp. 217-224.

Sarabdjitsingh, R.A., Spiga, F., Oitzl, M.S., Kershaw, Y., Meijer, O.C., Lightman, S.L., De Kloet, E.R. , Recovery from disrupted ultradian glucocorticoid rhythmicity reveals a dissociation between hormonal and behavioral stress responsiveness, J Neuroendocrinol, vol. 22, no. 8, pp. 862-871.

2009

de Kloet, E.R., Fitzsimons, C.P., Datson, N.A., Meijer, O.C., Vreugdenhil, E. , Glucocorticoid signaling and stress-related limbic susceptibility pathway: about receptors, transcription machinery and microRNA, Brain Res, vol. 1293, pp. 129-141.

Lachize, S.B., Apostolakis, E.M., van der Laan, S., Tijssen, A.M., Xu, J., de Kloet, E.R., Meijer, O.C. , Steroid receptor coactivator-1 is necessary for regulation of corticotropin-releasing hormone by chronic stress and glucocorticoids, PNAS, vol. 106, no. 19, pp. 8038-8042.

Vreugdenhil, E., Verissimo, C.S., Mariman, R., Kamphorst, J.T., Barbosa, J.S., Zweers, T., Champagne, D.L., Schouten, T., Meijer, O.C., de Kloet, E.R., Fitzsimons, C.P. , MicroRNA 18 and 124a down-regulate the glucocorticoid receptor: implications for glucocorticoid responsiveness in the brain, Endocrinology, vol. 150, no. 5, pp. 2220-2228.

Champagne, D.L., de Kloet, E.R., Joels, M. , Fundamental aspects of the impact of glucocorticoids on the (immature) brain, Semin Fetal Neonatal Med, vol. 14, no. 3, pp. 136-142.

de Jong, I.E., Steenbergen, P.J., de Kloet, E.R. , Behavioral sensitization to cocaine: cooperation between glucocorticoids and epinephrine, Psychopharmacology, vol. 204, no. 4, pp. 693-703.

Sarabdjitsingh, R.A., Meijer, O.C., Schaaf, M.J., de Kloet, E.R. , Subregion-specific differences in translocation patterns of mineralocorticoid and glucocorticoid receptors in rat hippocampus, Brain Res, vol. 1249, pp. 43-53.

de Jong, I.E., de Kloet, E.R. , Critical time-window for the actions of adrenal glucocorticoids in behavioural sensitisation to cocaine, Eur J Pharmacol, vol. 604, no. 1-3, pp. 66-73.

Revsin, Y., Rekers, N.V., Louwe, M.C., Saravia, F.E., De Nicola, A.F., de Kloet, E.R., Oitzl, M.S. , Glucocorticoid receptor blockade normalizes hippocampal alterations and cognitive impairment in streptozotocin-induced type 1 diabetes mice, Neuropsychopharmacology, vol. 34, no. 3, pp. 747-758.

Daskalakis, N.P., Kaperoni, M., Koros, C., de Kloet, E.R., Kitraki, E. , Environmental and tactile stimulation modulates the neonatal handling effect on adult rat spatial memory, Int J Dev Neurosci, vol. 27, no. 8, pp. 747-755.

Datson, N.A., Morsink, M.C., Steenbergen, P.J., Aubert, Y., Schlumbohm, C., Fuchs, E., de Kloet, E.R. , A molecular blueprint of gene expression in hippocampal subregions CA1, CA3, and DG is conserved in the brain of the common marmoset, Hippocampus, vol. 19, no. 8, pp. 739-752.

Brinks, V., Berger, S., Gass, P., de Kloet, E.R., Oitzl, M.S. , Mineralocorticoid receptors in control of emotional arousal and fear memory, Horm Behav, vol. 56, no. 2, pp. 232-238.

Brinks, V., de Kloet, E.R., Oitzl, M.S. , Corticosterone facilitates extinction of fear memory in BALB/c mice but strengthens cue related fear in C57BL/6 mice, Exp Neurol, vol. 216, no. 2, pp. 375-382.

De Kloet, E.R. , Neuroendocrine Aging: Pituitary-Adrenal Axis, Encyclopedia of Neuroscience, Oxford, Academic Press, pp. 309-315.

de Kloet, E.R. , Stress: a neurobiological perspective, Tijdschr Psychiatr, vol. 51, no. 8, pp. 541-550.

van der Laan, S., de Kloet, E.R., Meijer, O.C. , Timing is critical for effective glucocorticoid receptor mediated repression of the cAMP-induced CRH gene, PLoS One, vol. 4, no. 1, pp. 1-6.

Revsin, Y., de Kloet, E.R. , When glucocorticoids change from protective to harmful. Lessons from a type 1 diabetes animal model, Medicina-Buenos Aires, vol. 69, no. 3, pp. 353-358.

Brittijn, S.A., Duivesteijn, S.J., Belmamoune, M., Bertens, L.F., Bitter, W., de Bruijn, J.D., Champagne, D.L., Cuppen, E., Flik, G., Vandenbroucke-Grauls, C.M., Janssen, R.A., de Jong, I.M., de Kloet, E.R., Kros, A., Meijer, A.H., Metz, J.R., van der Sar, A.M., Schaaf, M.J., Schulte-Merker, S., Spaink, H.P., Tak, P.P., Verbeek, F.J., Vervoordeldonk, M.J., Vonk, F.J., Witte, F., Yuan, H., Richardson, M.K. , Zebrafish development and regeneration: new tools for biomedical research, Int J Dev Biol, vol. 53, no. 5-6, pp. 835-850.

2008

van der Laan, S., Sarabdjitsingh, R.A., Van Batenburg, M.F., Lachize, S.B., Li, H., Dijkmans, T.F., Vreugdenhil, E., de Kloet, E.R., Meijer, O.C. , Chromatin immunoprecipitation scanning identifies glucocorticoid receptor binding regions in the proximal promoter of a ubiquitously expressed glucocorticoid target gene in brain, J Neurochem, vol. 106, no. 6, pp. 2515-2523.

Dalm, S., Brinks, V., van der Mark, M.H., de Kloet, E.R., Oitzl, M.S. , Non-invasive stress-free application of glucocorticoid ligands in mice, J Neurosci Methods, vol. 170, no. 1, pp. 77-84.

de Jong, I.E., Steenbergen, P.J., de Kloet, E.R. , Strain differences in the effects of adrenalectomy on the midbrain dopamine system: implication for behavioral sensitization to cocaine, Neuroscience, vol. 153, no. 3, pp. 594-604.

de Kloet, E.R., de Jong, I.E., Oitzl, M.S. , Neuropharmacology of glucocorticoids: focus on emotion, cognition and cocaine, Eur J Pharmacol, vol. 585, no. 2-3, pp. 473-482.

de Kloet, E.R., Karst, H., Joels, M. , Corticosteroid hormones in the central stress response: quick-and-slow, Front Neuroendocrinol, vol. 29, no. 2, pp. 268-272.

Olijslagers, J.E., de Kloet, E.R., Elgersma, Y., van Woerden, G.M., Joels, M., Karst, H. , Rapid changes in hippocampal CA1 pyramidal cell function via pre- as well as postsynaptic membrane mineralocorticoid receptors, Eur J Neurosci, vol. 27, no. 10, pp. 2542-2550.

van der Veen, R., Abrous, D.N., de Kloet, E.R., Piazza, P.V., Koehl, M. , Impact of intra- and interstrain cross-fostering on mouse maternal care, Genes Brain Behav, vol. 7, no. 2, pp. 184-192.

Champagne, D.L., Bagot, R.C., van Hasselt, F., Ramakers, G., Meaney, M.J., de Kloet, E.R., Joels, M., Krugers, H. , Maternal care and hippocampal plasticity: evidence for experience-dependent structural plasticity, altered synaptic functioning, and differential responsiveness to glucocorticoids and stress, J Neurosci, vol. 28, no. 23, pp. 6037-6045.

Enthoven, L., de Kloet, E.R., Oitzl, M.S. , Differential development of stress system (re)activity at weaning dependent on time of disruption of maternal care, Brain Res, vol. 1217, pp. 62-69.

de Kloet, E.R. , About stress hormones and resilience to psychopathology, J Neuroendocrinol, vol. 20, no. 6, pp. 885-892.

Revsin, Y., van Wijk, D., Saravia, F.E., Oitzl, M.S., De Nicola, A.F., de Kloet, E.R. , Adrenal hypersensitivity precedes chronic hypercorticism in streptozotocin-induced diabetes mice, Endocrinology, vol. 149, no. 7, pp. 3531-3539.

de Kloet, E.R., Sarabdjitsingh, R.A. , Everything has rhythm: focus on glucocorticoid pulsatility, Endocrinology, vol. 149, no. 7, pp. 3241-3243.

Joels, M., Karst, H., de Rijk, R.H., de Kloet, E.R. , The coming out of the brain mineralocorticoid receptor, Trends Neurosci, vol. 31, no. 1, pp. 1-7.

Enthoven, L., de Kloet, E.R., Oitzl, M.S. , Effects of maternal deprivation of CD1 mice on performance in the water maze and swim stress, Behav Brain Res, vol. 187, no. 1, pp. 195-199.

van der Laan, S., Lachize, S.B., Vreugdenhil, E., de Kloet, E.R., Meijer, O.C. , Nuclear receptor coregulators differentially modulate induction and glucocorticoid receptor-mediated repression of the corticotropin-releasing hormone gene, Endocrinology, vol. 149, no. 2, pp. 725-732.

Fitzsimons, C.P., Ahmed, S., Wittevrongel, C.F., Schouten, T.G., Dijkmans, T.F., Scheenen, W.J., Schaaf, M.J., de Kloet, E.R., Vreugdenhil, E. , The microtubule-associated protein doublecortin-like regulates the transport of the glucocorticoid receptor in neuronal progenitor cells, Mol Endocrinol, vol. 22, no. 2, pp. 248-262.

Enthoven, L., Oitzl, M.S., Koning, N., van der Mark, M.H., de Kloet, E.R. , Hypothalamic-pituitary-adrenal axis activity of newborn mice rapidly desensitizes to repeated maternal absence but becomes highly responsive to novelty, Endocrinology, vol. 149, no. 12, pp. 6366-6377.

Dijkmans, T.F., van Hooijdonk, L.W., Schouten, T.G., Kamphorst, J.T., Vellinga, A.C., Meerman, J.H., Fitzsimons, C.P., de Kloet, E.R., Vreugdenhil, E. , Temporal and functional dynamics of the transcriptome during nerve growth factor-induced differentiation, J Neurochem, vol. 105, no. 6, pp. 2388-2403.

Datson, N.A., Morsink, M.C., Meijer, O.C., de Kloet, E.R. , Central corticosteroid actions: Search for gene targets, Eur J Pharmacol, vol. 583, no. 2-3, pp. 272-289.

De Rijk, R.H., de Kloet, E.R. , Corticosteroid receptor polymorphisms: determinants of vulnerability and resilience, Eur J Pharmacol, vol. 583, no. 2-3, pp. 303-311.

de Kloet, E.R., Han, F., Meijer, O.C. , From the stalk to down under about brain glucocorticoid receptors, stress and development, Neurochem Res, vol. 33, no. 4, pp. 637-642.

De Kloet, E.R., Datson, N.A., Revsin, Y., Champagne, D.L., Oitzl, M.S. , Brain Corticosteroid Receptor Function in Response to Psychosocial Stressors, Hormones and Social Behaviour, New York;Paris;Tokyo;, Springer, pp. 131-150.

Meijer, O.C., De Kloet, E.R. , Coregulators in CNS Function and Disease, Nuclear Receptor Coregulators and Human Diseases: World Scientific Publishing, pp. 383-408.

de Kloet, E.R. , Commentary: neuroendocrine basis, Prog Brain Res, vol. 167, pp. 53-62.

Berry, A., Greco, A., Giorgio, M., Pelicci, P.G., De Kloet, E.R., Alleva, E., Minghetti, L., Cirulli, F. , Deletion of the lifespan determinant p66(Shc) improves performance in a spatial memory task, decreases levels of oxidative stress markers in the hippocampus and increases levels of the neurotrophin BDNF in adult mice, Exp Gerontol, vol. 43, no. 3, pp. 200-208.

Wust, S., Kumsta, R., de Rijk, R.H., Entringer, S., van Rossum, E.F.C., De Kloet, E.R., Hellhammer, D.H., Koper, J.W. , Glucocorticoid and mineralocorticoid receptor gene variants are associated with ACTH, cortisol and cardiovascular responses to psychosocial stress, Int J Psychology, vol. 43, no. 3-4, pp. S063, 195-195.

van der Veen, R., Koehl, M., Abrous, D.N., de Kloet, E.R., Piazza, P.V., Deroche-Gamonet, V. , Maternal environment influences cocaine intake in adulthood in a genotype-dependent manner, PLoS One, vol. 3, no. 5, pp. 1-9.

de Kloet, E.R. , Nothing is carved in stone, Tijdschr Psychiatr, vol. 50, no. 12, pp. 781-783.

Brinks, V., de Kloet, E.R., Oitzl, M.S. , Strain specific fear behaviour and glucocorticoid response to aversive events: modelling PTSD in mice, Prog Brain Res, vol. 167, pp. 257-261.

2007

Schmidt, M.V., Oitzl, M.S., Steenbergen, P.J., Lachize, S.B., Wurst, W., Muller, M.B., de Kloet, E.R., Meijer, O.C. , Ontogeny of steroid receptor coactivators in the hippocampus and their role in regulating postnatal HPA axis function, Brain Res, vol. 1174, pp. 1-6.

Conway-Campbell, B.L., McKenna, M.A., Wiles, C.C., Atkinson, H.C., de Kloet, E.R., Lightman, S.L. , Proteasome-dependent down-regulation of activated nuclear hippocampal glucocorticoid receptors determines dynamic responses to corticosterone, Endocrinology, vol. 148, no. 11, pp. 5470-5477.

Morsink, M.C., Van Gemert, N.G., Steenbergen, P.J., Joels, M., De Kloet, E.R., Datson, N.A. , Rapid glucocorticoid effects on the expression of hippocampal neurotransmission-related genes, Brain Res, vol. 1150, pp. 14-20.

Schoonman, G.G., Evers, D.J., Ballieux, B.E., de Geus, E.J., de Kloet, E.R., Terwindt, G.M., van Dijk, J.G., Ferrari, M.D. , Is stress a trigger factor for migraine?, Psychoneuroendocrinology, vol. 32, no. 5, pp. 532-538.

Veenema, A.H., de Kloet, E.R., de Wilde, M.C., Roelofs, A.J., Kawata, M., Buwalda, B., Neumann, I.D., Koolhaas, J.M., Lucassen, P.J. , Differential effects of stress on adult hippocampal cell proliferation in low and high aggressive mice, J Neuroendocrinol, vol. 19, no. 7, pp. 489-498.

Berry, A., Capone, F., Giorgio, M., Pelicci, P.G., de Kloet, E.R., Alleva, E., Minghetti, L., Cirulli, F. , Deletion of the life span determinant p66Shc prevents age-dependent increases in emotionality and pain sensitivity in mice, Exp Gerontol, vol. 42, no. 1-2, pp. 37-45.

Sibug, R.M., Datson, N.A., Tijssen, A.M., Morsink, M.C., de Koning, J., de Kloet, E.R., Helmerhorst, F.M. , Effects of urinary and recombinant gonadotrophins on gene expression profiles during the murine peri-implantation period, Hum Reprod, vol. 22, no. 1, pp. 75-82.

de Jong, I.E., Oitzl, M.S., de Kloet, E.R. , Adrenalectomy prevents behavioural sensitisation of mice to cocaine in a genotype-dependent manner, Behav Brain Res, vol. 177, no. 2, pp. 329-339.

de Kloet, E.R., De Rijk, R.H., Meijer, O.C. , Therapy Insight: is there an imbalanced response of mineralocorticoid and glucocorticoid receptors in depression?, Nat Clin Pract Endocrinol Metab, vol. 3, no. 2, pp. 168-179.

Schenk, G.J., Engels, B.M., Zhang, Y.P., Fitzsimons, C.P., Schouten, T., Kruidering, M., de Kloet, E.R., Vreugdenhil, E. , A potential role for calcium / calmodulin-dependent protein kinase-related peptide in neuronal apoptosis: in vivo and in vitro evidence, Eur J Neurosci, vol. 26, no. 12, pp. 3411-3420.

Oomen, C.A., Mayer, J.L., de Kloet, E.R., Joels, M., Lucassen, P.J. , Brief treatment with the glucocorticoid receptor antagonist mifepristone normalizes the reduction in neurogenesis after chronic stress, Eur J Neurosci, vol. 26, no. 12, pp. 3395-3401.

Han, F., Ozawa, H., Matsuda, K. I, Lu, H., De Kloet, E.R., Kawata, M. , Changes in the expression of corticotrophin-releasing hormone, mineralocorticoid receptor and glucocorticoid receptor mRNAs in the hypothalamic paraventricular nucleus induced by fornix transection and adrenalectomy, J Neuroendocrinol, vol. 19, no. 4, pp. 229-38.

Meijer, O.C., De Kloet, E.R., McEwen, B.S. , Corticosteroid Receptors, Encyclopedia of Stress, vol. 2nd, New York, Elsevier / Academic Press, pp. 594-605.

Brinks, V., van der Mark, M.H., de Kloet, E.R., Oitzl, M.S. , Differential MR/GR activation in mice results in emotional states beneficial or impairing for cognition, Neural Plast, vol. 2007, no. Articlr ID, pp. 1-11.

Datson, N.A., Morsink, M.C., Atanasova, S., Armstrong, V.W., Zischler, H., Schlumbohm, C., Dutilh, B.E., Huynen, M.A., Waegele, B., Ruepp, A., de Kloet, E.R., Fuchs, E. , Development of the first marmoset-specific DNA microarray (EUMAMA): a new genetic tool for large-scale expression profiling in a non-human primate, BMC Genomics, vol. 8, no. 190, pp. 1-9.

Brinks, V., van der Mark, M.H., De Kloet, E.R., Oitzl, M.S. , Emotion and cognition in high and low stress sensitive mouse strains: a combined neuroendocrine and behavioral study in BALB/c and C57BL/6J mice, Front Behav Neurosci, vol. 1, no. 8, pp. 1-12.

de Rijk, R.H., De Kloet, E.R. , Mineralocorticoid Receptor Polymorphisms, Encyclopedia of Stress, vol. 2nd, New York, Elsevier / Academic Press, pp. 744-748.

De Kloet, E.R., Rinne, T. , Neuroendocrine markers of early trauma : implications for posttraumatic stress disorders, Traumatic dissociation neurobiology and treatment, vol. 1st ed, Washington, DC, American Psychiatric Pub, pp. 139-156.

Revsin, Y., Oitzl, M.S., Saravia, F.E., De Nicola, A.E., De Kloet, E.R. , Neuroendocrine markers in streptozotocin (STZ)-induced type 1 diabetes, Diabetologia, vol. 50, pp. S282-S283, 0684.

De Kloet, E.R., Oitzl, M.S., Vermetten, E. , Stress hormones and post traumatic stress disorder basic studies and clinical perspectives, Prog Brain Res, vol. 167, no. xviii, 320, Amsterdam, Elsevier, pp. 1-320.

Brinks, V., de Kloet, E.R., Oitzl, M.S. , Strain specific fear behaviour and glucocorticoid response to aversive events: modelling PTSD in mice, Stress Hormones and Post Traumatic Stress Disorder: Basic Studies and Clinical Perspectives, vol. 167, Amsterdam, Elsevier Science Bv, pp. 257-261.

De Kloet, E.R. , Stress System Balance Hypothesis, Encyclopedia of Stress, vol. 2nd, New York, Elsevier / Academic Press, pp. 646-650.

Helmerhorst, F.M., Sibug, R.M., De Kloet, E.R. , Stress Effect of Assisted Reproduction, Encyclopedia of Stress, vol. 2nd, New York, Elsevier / Academic Press, pp. 596-598.

Karssen, A.M., De Kloet, E.R. , Synthetic Glucocorticoids, Encyclopedia of Stress, vol. 2nd, New York, Elsevier / Academic Press, pp. 704-708.

Levine, S., De Kloet, E.R., Dent, G., Schmidt, M.V. , Stress Hyporesponsive Period, Encyclopedia of Stress, vol. 2nd, New York, Elsevier / Academic Press, pp. 606-611.

De Kloet, E.R. , Susceptibility or resilience to psychopathology? A question of stress, genes and balance, Eur Neuropsychopharmacol, vol. 17, pp. S173-S173.

Van Eekelen, J.A.M., Mattes, E., Foster, J.K., De Kloet, E.R., McKeague, I.W. , The effects of HPA development on adolescent brain maturation, Early Human Development, vol. 83, pp. S122-S123, P1-140.

2006

Schmidt, M.V., Deussing, J.M., Oitzl, M.S., Ohl, F., Levine, S., Wurst, W., Holsboer, F., Muller, M.B., de Kloet, E.R. , Differential disinhibition of the neonatal hypothalamic- pituitary-adrenal axis in brain-specific CRH receptor 1-knockout mice, Eur J Neurosci, vol. 24, no. 8, pp. 2291-2298.

Lucassen, P.J., Heine, V.M., Muller, M.B., van der Beek, E.M., Wiegant, V.M., De Kloet, E.R., Joels, M., Fuchs, E., Swaab, D.F., Czeh, B. , Stress, depression and hippocampal apoptosis, CNS Neurol Disord Drug Targets, vol. 5, no. 5, pp. 531-546.

van Leeuwen, N., Wust, S., Meijer, O.C., de Kloet, E.R., Zitman, F.G., de Rijk, R.H. , The role of single nucleotide polymorphisms (SNPs) in the mineralocorticoid receptor (MR) in stress response and psychopathology, American Journal of Medical Genetics Part B-Neuropsychiatric Genetics, vol. 141B, no. 7, pp. 752-752.

Schoonman, G.G., Evers, D.J., Ballieux, B.E., de Geus, E.J., de Kloet, E.R., Terwindt, G.M., van Dijk, J.G., Ferrari, M.D. , Is stress a trigger factor for migraine?, Cephalalgia, vol. 26, no. 11, pp. 1384-1385.

Schmidt, M.V., Levine, S., Alam, S., Harbich, D., Sterlemann, V., Ganea, K., de Kloet, E.R., Holsboer, F., Muller, M.B. , Metabolic signals modulate hypothalamic-pituitary-adrenal axis activation during maternal separation of the neonatal mouse, J Neuroendocrinol, vol. 18, no. 11, pp. 865-874.

Morsink, M.C., Joels, M., Sarabdjitsingh, R.A., Meijer, O.C., De Kloet, E.R., Datson, N.A. , The dynamic pattern of glucocorticoid receptor-mediated transcriptional responses in neuronal PC12 cells, J Neurochem, vol. 99, no. 4, pp. 1282-1298.

Feldker, D.E., Morsink, M.C., Veenema, A.H., Datson, N.A., Proutski, V., Lathouwers, D., de Kloet, E.R., Vreugdenhil, E. , The effect of chronic exposure to highly aggressive mice on hippocampal gene expression of non-aggressive subordinates, Brain Res, vol. 1089, no. 1, pp. 10-20.

Herbert, J., Goodyer, I.M., Grossman, A.B., Hastings, M.H., de Kloet, E.R., Lightman, S.L., Lupien, S.J., Roozendaal, B., Seckl, J.R. , Do corticosteroids damage the brain?, J Neuroendocrinol, vol. 18, no. 6, pp. 393-411.

Saravia, F.E., Beauquis, J., Revsin, Y., Homo-Delarche, F., de Kloet, E.R., De Nicola, A.F. , Hippocampal neuropathology of diabetes mellitus is relieved by estrogen treatment, Cell Mol Neurobiol, vol. 26, no. 4-6, pp. 943-957.

de Kloet, E.R. , From punch to profile, Neurochem Res, vol. 31, no. 2, pp. 131-135.

De Rijk, R.H., Wust, S., Meijer, O.C., Zennaro, M.C., Federenko, I.S., Hellhammer, D.H., Giacchetti, G., Vreugdenhil, E., Zitman, F.G., de Kloet, E.R. , A common polymorphism in the mineralocorticoid receptor modulates stress responsiveness, J Clin Endocrinol Metab, vol. 91, no. 12, pp. 5083-5089.

Mayer, J.L., Klumpers, L., Maslam, S., de Kloet, E.R., Joels, M., Lucassen, P.J. , Brief treatment with the glucocorticoid receptor antagonist mifepristone normalises the corticosterone-induced reduction of adult hippocampal neurogenesis, J Neuroendocrinol, vol. 18, no. 8, pp. 629-631.

Morsink, M.C., Steenbergen, P.J., Vos, J.B., Karst, H., Joels, M., De Kloet, E.R., Datson, N.A. , Acute activation of hippocampal glucocorticoid receptors results in different waves of gene expression throughout time, J Neuroendocrinol, vol. 18, no. 4, pp. 239-252.

De Kloet, E.R., Oitzl, M.S. , Cortisol and PTSD: Animal Experiments and Clinical Perspectives, PTSD, brain mechanisms and clinical implications, no. Part 1, New York, Springer, pp. 13-27.

Revsin, Y., van Wijk, D., Saravia, F.E., De Nicola, A.F., Oitzl, M.S., De Kloet, E.R. , HPA axis regulation reaches a new setpoint in acute and chronic type 1 diabetes: implications for brain pathology, Diabetologia, vol. 49, pp. 329-330.

De Kloet, E.R. , Neurodevelopmental setpoint and vulnerability to disease, Eur Neuropsychopharmacol, vol. 16, pp. S202-S202.

de Rijk, R.H., De Kloet, E.R. , Stress, glucocorticoids, and the brain, Nutrients, stress, and medical disorders, Totowa, N.J, Humana Press, pp. 111-135.

De Kloet, E.R., Sibug, R.M., Helmerhorst, F.M., Schmidt, M.V. , Stress, genes and the mechanism of programming the brain for later life (vol 29, pg 271, 2005), Neuroscience & Biobehavioral Reviews, vol. 30, no. 4, pp. 576-576.

Meijer, O.C., van der Laan, S., Lachize, S.B., Steenbergen, P.J., de Kloet, E.R. , Steroid receptor coregulator diversity: what can it mean for the stressed brain?, Neuroscience, vol. 138, no. 3, pp. 891-899.

Schmidt, M.V., Enthoven, L., van der Mark, M.H., Levine, S., De Kloet, E.R., Oitzl, M.S. , The postnatal development of the hypothalamic-pituitary-adrenal axis in the mouse (vol 23, pg 125, 2003), Int J Dev Neurosci, vol. 24, no. 4, pp. 293-293.

2005

van der Laan, S., Lachize, S.B., Schouten, T.G., Vreugdenhil, E., de Kloet, E.R., Meijer, O.C. , Neuroanatomical distribution and colocalisation of nuclear receptor corepressor (N-CoR) and silencing mediator of retinoid and thyroid receptors (SMRT) in rat brain, Brain Res, vol. 1059, no. 2, pp. 113-121.

Revsin, Y., Saravia, F., Roig, P., Lima, A., de Kloet, E.R., Homo-Delarche, F., De Nicola, A.F. , Neuronal and astroglial alterations in the hippocampus of a mouse model for type 1 diabetes, Brain Res, vol. 1038, no. 1, pp. 22-31.

Schmidt, M.V., Levine, S., Oitzl, M.S., van der Mark, M.H., Muller, M.B., Holsboer, F., de Kloet, E.R. , Glucocorticoid receptor blockade disinhibits pituitary-adrenal activity during the stress hyporesponsive period of the mouse, Endocrinology, vol. 146, no. 3, pp. 1458-1464.

Meijer, O.C., Kalkhoven, E., van der Laan, S., Steenbergen, P.J., Houtman, S.H., Dijkmans, T.F., Pearce, D., de Kloet, E.R. , Steroid receptor coactivator-1 splice variants differentially affect corticosteroid receptor signaling, Endocrinology, vol. 146, no. 3, pp. 1438-1448.

Sibug, R.M., de Koning, J., Tijssen, A.M., de Ruiter, M.C., de Kloet, E.R., Helmerhorst, F.M. , Urinary gonadotrophins but not recombinant gonadotrophins reduce expression of VEGF120 and its receptors flt-1 and flk-1 in the mouse uterus during the peri-implantation period, Hum Reprod, vol. 20, no. 3, pp. 649-656.

de Kloet, E.R., Joels, M., Holsboer, F. , Stress and the brain: from adaptation to disease, Nat Rev Neurosci, vol. 6, no. 6, pp. 463-475.

Veenema, A.H., Sijtsma, B., Koolhaas, J.M., de Kloet, E.R. , The stress response to sensory contact in mice: genotype effect of the stimulus animal, Psychoneuroendocrinology, vol. 30, no. 6, pp. 550-557.

De Rijk, R.H., de Kloet, E.R. , Corticosteroid receptor genetic polymorphisms and stress responsivity, Endocrine, vol. 28, no. 3, pp. 263-270.

Karssen, A.M., Meijer, O.C., Berry, A., Sanjuan Pinol, R., de Kloet, E.R. , Low doses of dexamethasone can produce a hypocorticosteroid state in the brain, Endocrinology, vol. 146, no. 12, pp. 5587-5595.

de Kloet, E.R., Sibug, R.M., Helmerhorst, F.M., Schmidt, M.V. , Stress, genes and the mechanism of programming the brain for later life, Neurosci Biobehav Rev, vol. 29, no. 2, pp. 271-281.

Dalm, S., Enthoven, L., Meijer, O.C., van der Mark, M.H., Karssen, A.M., de Kloet, E.R., Oitzl, M.S. , Age-related changes in hypothalamic-pituitary-adrenal axis activity of male C57BL/6J mice, Neuroendocrinology, vol. 81, no. 6, pp. 372-380.

Wust, S., de Rijk, R.H., Meijer, O.C., Federenko, I, Vreugdenhil, E., de Punder, K., Hellhammer, D., De Kloet, E.R. , A common mineralocorticoid receptor gene variant is associated with cortisol and heart rate response to psychosocial stress, J Psychophysiology, vol. 19, no. 2, pp. 154-155.

De Kloet, E.R., Schmidt, M.V., Meijer, O.C. , Corticosteroid receptors and HPA axis regulation, Handbook of stress and the brain, vol. 1, Amsterdam, Elsevier, pp. 265-295.

Karssen, A.M., Meijer, O.C., de Kloet, E.R. , Corticosteroids and the blood-brain barrier, Handbook of stress and the brain, vol. 1, Amsterdam, Elsevier, pp. 329-341.

Kruk, M.R., De Kloet, E.R. , Genen, glucocortico‹den en geweld, Tijdschrift voor Criminologie, vol. 47, no. 2, pp. 136-141.

Revsin, Y., Dalm, S., Saravia, F.E., Oitzl, M.S., De Nicola, A.F., De Kloet, E.R. , HPA axis regulation in type 1 diabetes, Diabetologia, vol. 48, pp. A234-A234.

Schmidt, M.V., Oitzl, M.S., Muller, M.B., Ohl, F., Wurst, W., Holsboer, F., Levine, S., De Kloet, E.R. , Regulation of the developing hypothalamic-pituitary-adrenal axis in corticotropin releasing hormone receptor 1-deficient mice (vol 119, pg 589, 2003), Neuroscience, vol. 135, no. 4, pp. 1343-1343.

De Kloet, E.R. , Stress, cortisol and cognition: Towards understanding a vulnerable phenotype for stress-related psychopathology, Nordic Journal of Psychiatry, vol. 59, no. 5, pp. 398-398.

Oitzl, M.S., Enthoven, L., De Kloet, E.R. , Stress system regulation, glucocorticoid receptors and traumatic early life events, Eur Psychiatry, vol. 20, no. Suppl-1, pp. S102-S102.

Schmidt, M.V., Oitzl, M.S., Levine, S., De Kloet, E.R. , The HPA system during the postnatal development of CD1 mice and the effects of maternal deprivation (vol 139, pg 39, 2002), Developmental Brain Research, vol. 160, no. 2, pp. 287-287.

2004

Datson, N.A., Meijer, L., Steenbergen, P.J., Morsink, M.C., van der Laan, S., Meijer, O.C., de Kloet, E.R. , Expression profiling in laser-microdissected hippocampal subregions in rat brain reveals large subregion-specific differences in expression, Eur J Neurosci, vol. 20, no. 10, pp. 2541-2554.

Veenema, A.H., Koolhaas, J.M., de Kloet, E.R. , Basal and stress-induced differences in HPA axis, 5-HT responsiveness, and hippocampal cell proliferation in two mouse lines, Ann N Y Acad Sci, vol. 1018, pp. 255-265.

de Jong, I.E., de Kloet, E.R. , Glucocorticoids and vulnerability to psychostimulant drugs: toward substrate and mechanism, Ann N Y Acad Sci, vol. 1018, pp. 192-198.

De Kloet, E.R. , Hormones and the stressed brain, Ann N Y Acad Sci, vol. 1018, pp. 1-15.

Grootendorst, J., Enthoven, L., Dalm, S., de Kloet, E.R., Oitzl, M.S. , Increased corticosterone secretion and early-onset of cognitive decline in female apolipoprotein E-knockout mice, Behav Brain Res, vol. 148, no. 1-2, pp. 167-177.

Schmidt, M.V., Enthoven, L., van Woezik, J.H., Levine, S., de Kloet, E.R., Oitzl, M.S. , The dynamics of the hypothalamic-pituitary-adrenal axis during maternal deprivation, J Neuroendocrinol, vol. 16, no. 1, pp. 52-57.

Karssen, A.M., Meijer, O.C., Pons, D., De Kloet, E.R. , Localization of mRNA expression of P-glycoprotein at the blood-brain barrier and in the hippocampus, Ann N Y Acad Sci, vol. 1032, pp. 308-311.

De Kloet, E.R., De Rijk, R.H. , Signaling pathways in brain involved in predisposition and pathogenesis of stress-related disease: genetic and kinetic factors affecting the MR/GR balance, Ann N Y Acad Sci, vol. 1032, pp. 14-34.

Enthoven, L., Dalm, S., de Kloet, E.R., Oitzl, M.S. , Swim posture of mice does not affect performance in the water maze, Brain Res, vol. 1003, no. 1-2, pp. 36-41.

De Kloet, E.R., de Kloet, S.R. , Analysis of the beak and feather disease viral genome indicates the existence of several genotypes which have a complex psittacine host specificity, Arch Virol, vol. 149, no. 12, pp. 2393-2412.

De Kloet, E.R. , Corticosteroiden, Farmacologie, Utrecht, Wetenschappelijke Uitgeverij Bunge, pp. 212-224.

De Kloet, E.R., Karssen, A.M., Meijer, O.C., Oitzl, M.S. , Central effects of glucocorticoid antagonists: Preclinical studies, Biol Psychiatry, vol. 55, no. 8, Suppl-1, pp. 190S-191S.

de Jong, I.E.M., Oitzl, M.S., De Kloet, E.R. , Genetic background and glucocorticoid hormones contribute to individual differences in sensitivity of mice to cocaine, Behavioural Pharmacology, vol. 15, no. 5-6, pp. A13-A13.

Fauser, B.J.C.M., De Kloet, E.R., Lips, P., Michels, R.P.J., Wiersinga, W.M., Sitsen, J.M.A., van Wimersma Greidanus, T.B. , Hormonen, Farmacologie, Maarssen, Elsevier Gezondheidszorg.

Mulder, M., Jansen, P.J., Janssen, B.J., van de Berg, W.D., van der Boom, H., Havekes, L.M., De Kloet, E.R., Ramaekers, F.C., Blokland, A. , Low-density lipoprotein receptor-knockout mice display impaired spatial memory associated with a decreased synaptic density in the hippocampus, Neurobiol Dis, vol. 16, no. 1, pp. 212-219.

de Rijk, R.H., Zitman, F.G., De Kloet, E.R. , Neuroendocrinologie van de stress respons, Handboek voor Neurobiologische Psychiatrie: De Tijdstroom, pp. 65-85.

van der Beek, E.M., Wiegant, V.M., Schouten, W.G., van Eerdenburg, F.J., Loijens, L.W., van der Plas, C., Benning, M.A., de Vries, H., de Kloet, E.R., Lucassen, P.J. , Neuronal number, volume, and apoptosis of the left dentate gyrus of chronically stressed pigs correlate negatively with basal saliva cortisol levels, Hippocampus, vol. 14, no. 6, pp. 688-700.

De Kloet, E.R. , Obituary: In Honour of David de Wied, Psychoneuroendocrinology, vol. 29, no. 7, pp. 823-824.

van Praag, H.M., De Kloet, E.R., van Os, J. , Stress, the brain and depression, , no. xii, 283 p, Cambridge, UK, Cambridge University Press.

Rinne, T., van den Brink, W., Goekoop, J., de Rijk, R.H., De Kloet, E.R. , The neuro-endocrine scars of childhood abuse in female borderline personality disorder patients, Eur Psychiatry, vol. 19, no. Suppl-1, pp. 1S-1S, S11.02.

Sibug, R.M., de Koning, J., De Kloet, E.R., Helmerhorst, F.M. , VEGF(120) and its receptors Flt-1 and Flk-1 in the mouse uterus during the peri-implantation period are downregulated by urinary gonadotropins but not by recombinant gonadotropins, J Society for Gynecologic Investigation, vol. 11, no. Suppl-2, pp. 286A-286A.

2003

Feldker, D.E., de Kloet, E.R., Kruk, M.R., Datson, N.A. , Large-scale gene expression profiling of discrete brain regions: potential, limitations, and application in genetics of aggressive behavior, Behav Genet, vol. 33, no. 5, pp. 537-48.

de Kloet, E.R., Oitzl, M.S. , Who cares for a stressed brain? The mother, the kid or both?, Neurobiol Aging, vol. 24 Suppl 1, pp. S61-5; discussion S67-8.

Schmidt, M.V., Enthoven, L., van der Mark, M.H., Levine, S., de Kloet, E.R., Oitzl, M.S. , The postnatal development of the hypothalamic-pituitary-adrenal axis in the mouse, Int J Dev Neurosci, vol. 21, no. 3, pp. 125-132.

Veenema, A.H., Meijer, O.C., de Kloet, E.R., Koolhaas, J.M. , Genetic selection for coping style predicts stressor susceptibility, J Neuroendocrinol, vol. 15, no. 3, pp. 256-67.

de Kloet, E.R. , Hormones, brain and stress, Endocr Regul, vol. 37, no. 2, pp. 51-68.

Meijer, O.C., Karssen, A.M., de Kloet, E.R. , Cell- and tIssue-specific effects of corticosteroids in relation to glucocorticoid resistance: examples from the brain, J Endocrinol, vol. 178, no. 1, pp. 13-18.

Veenema, A.H., Meijer, O.C., de Kloet, E.R., Koolhaas, J.M., Bohus, B.G. , Differences in basal and stress-induced HPA regulation of wild house mice selected for high and low aggression, Horm Behav, vol. 43, no. 1, pp. 197-204.

Rinne, T., de Kloet, E.R., Wouters, L., Goekoop, J.G., de Rijk, R.H., van den Brink, W. , Fluvoxamine reduces responsiveness of HPA axis in adult female BPD patients with a history of sustained childhood abuse, Neuropsychopharmacology, vol. 28, no. 1, pp. 126-132.

Feldker, D.E., Datson, N.A., Veenema, A.H., Meulmeester, E., de Kloet, E.R., Vreugdenhil, E. , Serial analysis of gene expression predicts structural differences in hippocampus of long attack latency and short attack latency mice, Eur J Neurosci, vol. 17, no. 2, pp. 379-387.

Feldker, D.E., Datson, N.A., Veenema, A.H., Proutski, V., Lathouwers, D., De Kloet, E.R., Vreugdenhil, E. , GeneChip analysis of hippocampal gene expression profiles of short- and long-attack-latency mice: technical and biological implications, J Neurosci Res, vol. 74, no. 5, pp. 701-16.

De Rijk, R.H., Schaaf, M.J., Stam, F.J., de Jong, I.E., Swaab, D.F., Ravid, R., Vreugdenhil, E., Cidlowski, J.A., de Kloet, E.R., Lucassen, P.J. , Very low levels of the glucocorticoid receptor beta isoform in the human hippocampus as shown by Taqman RT-PCR and immunocytochemistry, Brain Res Mol Brain Res, vol. 116, no. 1-2, pp. 17-26.

Buitelaar, J.K., De Kloet, E.R., Oitzl, M.S. , Discussion to "Prenatal stress and cognitive development and temperament in infants" by Jan K. Buitelaar et al. and "Who cares for stress in the brain? The mother, the kid, or both" by E. Ronald de Kloet and Melly S. Oitzl, Neurobiol Aging, vol. 24, no. Supplement, pp. S67-S68.

de Jong, I.E.M., Oitzl, M.S., De Kloet, E.R. , Differential effects of glucocorticoids on the dopaminergic reward system in two genetically distinct mouse strains, Behavioural Pharmacology, vol. 14, no. Suppl-1, pp. S78-S78.

Finch, C.E., De Kloet, E.R., Visser, G.H.A., Buitelaar, J.K., Kessler, R., De Wied, D. , Discussion to "Prenatal stress and cognitive development and temperament in infants" by Jan K. Buitelaar et al. and "Who cares for stress in the brain? The mother, the kid, or both" by E. Ronald de Kloet and Melly S. Oitzl, Neurobiol Aging, vol. 24, pp. Suppl-1, S67-S68.

Pfaff, D.W., Swaab, D.F., Finch, C.E., Kessler, R., Buitelaar, J.K., Heuser, I, Brosens, I, Slob, A.K., De Kloet, E.R., Goodwin, G.M. , Discussion to 'Sex differences in the hypothalamus in the different stages of human life' by Dick E Swaab et al, Neurobiol Aging, vol. 24, pp. Suppl-1, S17-S19.

Sultan, C., Pfaff, D.W., Slob, A.K., Swaab, D.F., De Kloet, E.R. , Discussion to 'Hormonal and genetic influences underlying arousal as it drives sex and aggression in animal and human brains' by Jessica A. Mong and Donald W. Pfaff and 'Sexual behavior in (human) adults' by A. Koos Slob, Neurobiol Aging, vol. 24, pp. S91-S92.

Toussaint, O., Heuser, I, Thijssen, J.H.H., Finch, C.E., Swaab, D.F., De Kloet, E.R., Saletu, B., De Wied, D. , Discussion to "Stress and the brain" by Isabella Heuser and Claas-Hinrich Lammers and "Stress and aging: theoretical and empirical challenges for interdisciplinary research" by Jacqui Smith, Neurobiol Aging, vol. 24, pp. S81-S82.

De Kloet, E.R. , Neurosteroïden, Ned Tijdschr Klin Chem, vol. 28, pp. 179-182.

2002

Grootendorst, J., Kempes, M.M., Lucassen, P.J., Dalm, S., de Kloet, E.R., Oitzl, M.S. , Differential effect of corticosterone on spatial learning abilities in apolipoprotein E knockout and C57BL/6J mice, Brain Res, vol. 953, no. 1-2, pp. 281-285.

Karssen, A.M., Meijer, O.C., van der Sandt, I.C., De Boer, A.G., De Lange, E.C., De Kloet, E.R. , The role of the efflux transporter P-glycoprotein in brain penetration of prednisolone, J Endocrinol, vol. 175, no. 1, pp. 251-260.

Sibug, R.M., Helmerhorst, F.M., Tijssen, A.M., de Kloet, E.R., de Koning, J. , Estrogen reduces vascular endothelial growth factor(164) expression in the mouse nucleus paraventricularis of the hypothalamus, Neurosci Lett, vol. 333, no. 3, pp. 199-202.

Schmidt, M.V., Oitzl, M.S., Levine, S., de Kloet, E.R. , The HPA system during the postnatal development of CD1 mice and the effects of maternal deprivation, Brain Res Dev Brain Res, vol. 139, no. 1, pp. 39-49.

de Kloet, E.R., Grootendorst, J., Karssen, A.M., Oitzl, M.S. , Gene x environment interaction and cognitive performance: animal studies on the role of corticosterone, Neurobiol Learn Mem, vol. 78, no. 3, pp. 570-7.

De Rijk, R.H., Schaaf, M.J., de Kloet, E.R. , Glucocorticoid receptor variants: clinical implications, J Steroid Biochem Mol Biol, vol. 81, no. 2, pp. 103-22.

Sibug, R.M., Helmerhorst, F.M., Tijssen, A.M., de Kloet, E.R., de Koning, J. , Gonadotrophin stimulation reduces VEGF(120) expression in the mouse uterus during the peri-implantation period, Hum Reprod, vol. 17, no. 6, pp. 1643-1648.

van Acker, S.A., Oitzl, M.S., Fluttert, M.F., de Kloet, E.R. , Centrally regulated blood pressure response to vasoactive peptides is modulated by corticosterone, J Neuroendocrinol, vol. 14, no. 1, pp. 56-63.

Rahmouni, K., Sibug, R.M., De Kloet, E.R., Barthelmebs, M., Grima, M., Imbs, J.L., De Jong, W. , Effects of brain mineralocorticoid receptor blockade on blood pressure and renal functions in DOCA-salt hypertension, Eur J Pharmacol, vol. 436, no. 3, pp. 207-16.

van den Buuse, M., van Acker, S.A., Fluttert, M.F., de Kloet, E.R. , Involvement of corticosterone in cardiovascular responses to an open-field novelty stressor in freely moving rats, Physiol Behav, vol. 75, no. 1-2, pp. 207-15.

Van Kampen, M., De Kloet, E.R., Flugge, G., Fuchs, E. , Blockade of glucocorticoid receptors with ORG 34116 does not normalize stress-induced symptoms in male tree shrews, Eur J Pharmacol, vol. 457, no. 2-3, pp. 207-16.

Rinne, T., de Kloet, E.R., Wouters, L., Goekoop, J.G., De Rijk, R.H., van den Brink, W. , Hyperresponsiveness of hypothalamic-pituitary-adrenal axis to combined dexamethasone/corticotropin-releasing hormone challenge in female borderline personality disorder subjects with a history of sustained childhood abuse, Biol Psychiatry, vol. 52, no. 11, pp. 1102-12.

Evans, S.J., Datson, N.A., Kabbaj, M., Thompson, R.C., Vreugdenhil, E., De Kloet, E.R., Watson, S.J., Akil, H. , Evaluation of Affymetrix Gene Chip sensitivity in rat hippocampal tissue using SAGE analysis. Serial Analysis of Gene Expression, Eur J Neurosci, vol. 16, no. 3, pp. 409-413.

De Kloet, E.R., Oitzl, M.S., Vreugdenhil, E. , Brain corticosteroid receptors and responsive genes: Targets for therapy of stress-related disorders, Br J Pharmacol, vol. 135, pp. Suppl, 401P.

Joels, M., Krugers, H.J., De Kloet, E.R. , Corticosteroid actions on electrical activity in the brain, Hormones, Brain and Behavior, vol. 3, San Diego, CA., USA, Academic Press/Elsevier-Science, pp. 601-626.

Mulder, M., Janssen, B., Jansen, P., Van de Berg, W., Blokland, A., Havekes, L., De Kloet, E.R. , Impaired memory and reduced synaptic plasticity in low-density lipoprotein receptor-knockout mice, Neurobiol Aging, vol. 23, no. 1, pp. S244-S245.

De Kloet, E.R. , Stress in the brain: implications for treatment of depression, Acta Neuropsychiatrica, vol. 14, no. 4, pp. 155-166.

2001

Van Acker, S.A., Fluttert, M.F., Sibug, R.M., De Kloet, E.R. , Intracerebroventricular administration of a glucocorticoid receptor antagonist enhances the cardiovascular responses to brief restraint stress, Eur J Pharmacol, vol. 430, no. 1, pp. 87-91.

Oitzl, M.S., Reichardt, H.M., Joels, M., de Kloet, E.R. , Point mutation in the mouse glucocorticoid receptor preventing DNA binding impairs spatial memory, PNAS, vol. 98, no. 22, pp. 12790-12795.

Vreugdenhil, E., Engels, B.M., Middelburg, R., van Koningsbruggen, S., Knol, J., Veldhuisen, B., de Kloet, E.R. , Multiple transcripts generated by the DCAMKL gene are expressed in the rat hippocampus, Brain Res Mol Brain Res, vol. 94, no. 1-2, pp. 67-74.

Schaaf, M.J., Workel, J.O., Lesscher, H.M., Vreugdenhil, E., Oitzl, M.S., de Kloet, E.R. , Correlation between hippocampal BDNF mRNA expression and memory performance in senescent rats, Brain Res, vol. 915, no. 2, pp. 227-33.

Visser, J., Graffelman, W., Blauw, B., Haspels, I, Lentjes, E., de Kloet, E.R., Nagelkerken, L. , LPS-induced IL-10 production in whole blood cultures from chronic fatigue syndrome patients is increased but supersensitive to inhibition by dexamethasone, J Neuroimmunol, vol. 119, no. 2, pp. 343-349.

Grootendorst, J., de Kloet, E.R., Vossen, C., Dalm, S., Oitzl, M.S. , Repeated exposure to rats has persistent genotype-dependent effects on learning and locomotor activity of apolipoprotein E knockout and C57Bl/6 mice, Behav Brain Res, vol. 125, no. 1-2, pp. 249-59.

De Rijk, R.H., Schaaf, M.J., Turner, G., Datson, N.A., Vreugdenhil, E., Cidlowski, J., de Kloet, E.R., Emery, P., Sternberg, E.M., Detera-Wadleigh, S.D. , A human glucocorticoid receptor gene variant that increases the stability of the glucocorticoid receptor beta-isoform mRNA is associated with rheumatoid arthritis, J Rheumatol, vol. 28, no. 11, pp. 2383-8.

Grootendorst, J., Oitzl, M.S., Dalm, S., Enthoven, L., Schachner, M., de Kloet, E.R., Sandi, C. , Stress alleviates reduced expression of cell adhesion molecules (NCAM, L1), and deficits in learning and corticosterone regulation of apolipoprotein E knockout mice, Eur J Neurosci, vol. 14, no. 9, pp. 1505-1514.

van den Buuse, M., Van Acker, S.A., Fluttert, M.F., De Kloet, E.R. , Blood pressure, heart rate, and behavioral responses to psychological "novelty" stress in freely moving rats, Psychophysiology, vol. 38, no. 3, pp. 490-499.

Karssen, A.M., Meijer, O.C., van der Sandt, I.C., Lucassen, P.J., de Lange, E.C., de Boer, A.G., de Kloet, E.R. , Multidrug resistance P-glycoprotein hampers the access of cortisol but not of corticosterone to mouse and human brain, Endocrinology, vol. 142, no. 6, pp. 2686-2694.

Mulder, M., Blokland, A., van den Berg, D.J., Schulten, H., Bakker, A.H., Terwel, D., Honig, W., de Kloet, E.R., Havekes, L.M., Steinbusch, H.W., de Lange, E.C. , Apolipoprotein E protects against neuropathology induced by a high-fat diet and maintains the integrity of the blood-brain barrier during aging, Lab Invest, vol. 81, no. 7, pp. 953-60.

Lucassen, P.J., Vollmann-Honsdorf, G.K., Gleisberg, M., Czeh, B., De Kloet, E.R., Fuchs, E. , Chronic psychosocial stress differentially affects apoptosis in hippocampal subregions and cortex of the adult tree shrew, Eur J Neurosci, vol. 14, no. 1, pp. 161-166.

Workel, J.O., Oitzl, M.S., Fluttert, M.F., Lesscher, H., Karssen, A.M., de Kloet, E.R. , Differential and age-dependent effects of maternal deprivation on the hypothalamic-pituitary-adrenal axis of brown norway rats from youth to senescence, J Neuroendocrinol, vol. 13, no. 7, pp. 569-80.

Lucassen, P.J., Muller, M.B., Holsboer, F., Bauer, J., Holtrop, A., Wouda, J., Hoogendijk, W.J., De Kloet, E.R., Swaab, D.F. , Hippocampal apoptosis in major depression is a minor event and absent from subareas at risk for glucocorticoid overexposure, Am J Pathol, vol. 158, no. 2, pp. 453-68.

Vreugdenhil, E., de Kloet, E.R., Schaaf, M.J., Datson, N.A. , Genetic dissection of corticosterone receptor function in the rat hippocampus, Eur Neuropsychopharmacol, vol. 11, no. 6, pp. 423-30.

Sibug, R.M., Oitzl, M.S., Workel, J.O., de Kloet, E.R. , Maternal deprivation increases 5-HT(1A) receptor expression in the CA1 and CA3 areas of senescent Brown Norway rats, Brain Res, vol. 912, no. 1, pp. 95-8.

Datson, N.A., van der Perk, J., de Kloet, E.R., Vreugdenhil, E. , Identification of corticosteroid-responsive genes in rat hippocampus using serial analysis of gene expression, Eur J Neurosci, vol. 14, no. 4, pp. 675-689.

de Rijk, R.H., Meijer, O.C., De Kloet, E.R. , Brain corticosteroid receptors: targets for treatment of depression, Physical Consequences of Depression, Petersfield, UK, Wrightson Biomedical Pub, pp. 23-52.

De Kloet, E.R. , Corticosteroiden, Farmacologie, Utrecht, Wetenschappelijke Uitgeverij Bunge, pp. 194-205.

Kipling, ., Hoeijmakers, ., Kenemans, ., Naftolin, ., De Kloet, E.R., Gompel, . , DNA repair mechanisms - Discussion, Maturitas, vol. 38, no. 1, pp. 22-23.

Datson, N.A., van der Perk, J., de Kloet, E.R., Vreugdenhil, E. , Expression profile of 30,000 genes in rat hippocampus using SAGE, Hippocampus, vol. 11, no. 4, pp. 430-44.

Lucassen, P.J., De Kloet, E.R. , Glucocorticoids and the Aging Brain: Cause or Consequence?, Functional Neurobiology of Aging, San Diego, Calif, Academic, pp. 883-905.

Visser, J., Lentjes, E., Haspels, I, Graffelman, W., Blauw, B., De Kloet, E.R., Nagelkerken, L. , Increased sensitivity to glucocorticoids in peripheral blood mononuclear cells of chronic fatigue syndrome patients, without evidence for altered density or affinity of glucocorticoid receptors, J Investig Med, vol. 49, no. 2, pp. 195-204.

Rinne, T., van den Brink, W., Goekoop, J.G., de Rijk, R.H., De Kloet, E.R. , Neuroendocrine scars of severe childhood abuse in adult female borderline patients, Biol Psychiatry, vol. 49, no. 8, pp. 71S-71S.

Grootendorst, J., de Kloet, E.R., Dalm, S., Oitzl, M.S. , Reversal of cognitive deficit of apolipoprotein E knockout mice after repeated exposure to a common environmental experience, Neuroscience, vol. 108, no. 2, pp. 237-47.

De Kloet, E.R. , Stress in de Hersenen, Natuurkundige Voordrachten, vol. Nieuwe ree, Alphen a/d Rijn, Vis Offset, pp. 104-110.

Gompel, ., Kipling, ., Ropers, ., Naftolin, ., De Kloet, E.R. , Telomeres, replicative senescence and human ageing - Discussion, Maturitas, vol. 38, no. 1, pp. 37-38.

Ropers, ., Diczfalusy, ., De Kloet, E.R., Hulka, . , The demographic revolution and our common future - Discussion, Maturitas, vol. 38, no. 1, pp. 14-15.

2000

de Kloet, E.R. , Stress in the brain, Eur J Pharmacol, vol. 405, no. 1-3, pp. 187-98.

Sibug, R.M., Compaan, J.C., Meijer, O.C., Van der Gugten, J., Olivier, B., De Kloet, E.R. , Effects of flesinoxan on corticosteroid receptor expression in the rat hippocampus, Eur J Pharmacol, vol. 404, no. 1-2, pp. 111-9.

Karst, H., Karten, Y.J., Reichardt, H.M., de Kloet, E.R., Schutz, G., Joels, M. , Corticosteroid actions in hippocampus require DNA binding of glucocorticoid receptor homodimers, Nat Neurosci, vol. 3, no. 10, pp. 977-8.

Oitzl, M.S., Workel, J.O., Fluttert, M.F., Frosch, F., De Kloet, E.R. , Maternal deprivation affects behaviour from youth to senescence: amplification of individual differences in spatial learning and memory in senescent Brown Norway rats, Eur J Neurosci, vol. 12, no. 10, pp. 3771-3780.

Schaaf, M.J., De Kloet, E.R., Vreugdenhil, E. , Corticosterone effects on BDNF expression in the hippocampus. Implications for memory formation, Stress, vol. 3, no. 3, pp. 201-208.

Grootendorst, J., Mulder, M., Haasdijk, E., de Kloet, E.R., Jaarsma, D. , Presence of apolipoprotein E immunoreactivity in degenerating neurones of mice is dependent on the severity of kainic acid-induced lesion, Brain Res, vol. 868, no. 2, pp. 165-75.

Meijer, O.C., Steenbergen, P.J., De Kloet, E.R. , Differential expression and regional distribution of steroid receptor coactivators SRC-1 and SRC-2 in brain and pituitary, Endocrinology, vol. 141, no. 6, pp. 2192-2199.

Schaaf, M.J., Duurland, R., de Kloet, E.R., Vreugdenhil, E. , Circadian variation in BDNF mRNA expression in the rat hippocampus, Brain Res Mol Brain Res, vol. 75, no. 2, pp. 342-344.

Dalm, S., Grootendorst, J., de Kloet, E.R., Oitzl, M.S. , Quantification of swim patterns in the Morris water maze, Behav Res Methods Instrum Comput, vol. 32, no. 1, pp. 134-139.

de Kloet, E.R., Meijer, O.C., Vreugdenhil, E., Joels, M. , The Yin and Yang of nuclear receptors: symposium on nuclear receptors in brain, Oegstgeest, The Netherlands, 13-14 April 2000, Trends Endocrinol Metab, vol. 11, no. 6, pp. 245-8.

de Kloet, E.R., Van Acker, S.A., Sibug, R.M., Oitzl, M.S., Meijer, O.C., Rahmouni, K., de Jong, W. , Brain mineralocorticoid receptors and centrally regulated functions, Kidney Int, vol. 57, no. 4, pp. 1329-36.

Visser, J.T., De Kloet, E.R., Nagelkerken, L. , Altered glucocorticoid regulation of the immune response in the chronic fatigue syndrome, Ann N Y Acad Sci, vol. 917, pp. 868-75.

Meijer, O.C., De Kloet, E.R., McEwen, B.S. , Corticosteroid Receptors, Encyclopedia of Stress, vol. 1st, New York, Academic Press, pp. 557-569.

Lucassen, P.J., Vollmann-Honsdorf, G.K., Gleisberg, M., De Kloet, E.R., Fuchs, E. , Chronic psychosocial stress differentially influences the occurrence of apoptosis in the adult tree shrew hippocampus and cortex, Eur J Neurosci, vol. 12, pp. 303-303.

Oitzl, M.S., Grootendorst, J., Joels, M., Reichardt, H.M., Schutz, G., De Kloet, E.R. , Facilitation of spatial learning requires DNA-binding of the glucocorticoid receptor, Eur J Neurosci, vol. 12, pp. 170-170.

Karssen, A.M., De Kloet, E.R. , Synthetic Glucocorticoids, Encyclopedia of Stress, vol. 1st, New York, Academic Press, pp. 566-570.

Levine, S., Dent, G., De Kloet, E.R. , Stress Hyporesponsive Period, Encyclopedia of Stress, vol. 1st, New York, Academic Press, pp. 518-526.

Cabrera, R., Korte, S.M., Lentjes, E.G., Romijn, F., Schonbaum, E., De Nicola, A., De Kloet, E.R. , The amount of free corticosterone is increased during lipopolysaccharide-induced fever, Life Sci, vol. 66, no. 7, pp. 553-562.

Haller, J., Millar, S., van de Schraaf, J., De Kloet, E.R., Kruk, M.R. , The active phase-related increase in corticosterone and aggression are linked, J Neuroendocrinol, vol. 12, no. 5, pp. 431-436.

1999

de Kloet, E.R., Oitzl, M.S., Joels, M. , Stress and cognition: are corticosteroids good or bad guys?, Trends Neurosci, vol. 22, no. 10, pp. 422-6.

Datson, N.A., van der Perk-de Jong, J., van den Berg, M.P., de Kloet, E.R., Vreugdenhil, E. , MicroSAGE: a modified procedure for serial analysis of gene expression in limited amounts of tissue, Nucleic Acids Res, vol. 27, no. 5, pp. 1300-1307.

Karst, H., de Kloet, E.R., Joels, M. , Episodic corticosterone treatment accelerates kindling epileptogenesis and triggers long-term changes in hippocampal CA1 cells, in the fully kindled state, Eur J Neurosci, vol. 11, no. 3, pp. 889-898.

Saravia, F.E., Grillo, C.A., Ferrini, M., Roig, P., Lima, A.E., de Kloet, E.R., De Nicola, A.F. , Changes of hypothalamic and plasma vasopressin in rats with deoxycorticosterone-acetate induced salt appetite, J Steroid Biochem Mol Biol, vol. 70, no. 1-3, pp. 47-57.

Engels, B.M., Lucassen, P.J., de Kloet, E.R., Vreugdenhil, E. , Regional distribution of a novel calcium/calmodulin-dependent protein kinase mRNA in the rat brain, Brain Res, vol. 835, no. 2, pp. 365-8.

Schaaf, M.J., Sibug, R.M., Duurland, R., Fluttert, M.F., Oitzl, M.S., De Kloet, E.R., Vreugdenhil, E. , Corticosterone effects on BDNF mRNA expression in the rat hippocampus during morris water maze training, Stress, vol. 3, no. 2, pp. 173-183.

van Oers, H.J., de Kloet, E.R., Levine, S. , Persistent effects of maternal deprivation on HPA regulation can be reversed by feeding and stroking, but not by dexamethasone, J Neuroendocrinol, vol. 11, no. 8, pp. 581-8.

Vreugdenhil, E., Datson, N.A., Engels, B.M., de Jong, J., van Koningsbruggen, S., Schaaf, M.J., de Kloet, E.R. , Kainate-elicited seizures induce mRNA encoding a CaMK-related peptide: a putative modulator of kinase activity in rat hippocampus, J Neurobiol, vol. 39, no. 1, pp. 41-50.

De Kloet, E.R. , Genetische verschillen in stressreacties, Ziekten maken en breken. Over farmacogenomie, Amsterdam, Boom/Belvédère, pp. 76-83.

De Kloet, E.R. , Neurobiology of diseases in adaptation, Acta Neuropsychiatrica, vol. 11, no. 1, pp. 11-14.

1998

Mulder, M., Ravid, R., Swaab, D.F., de Kloet, E.R., Haasdijk, E.D., Julk, J., van der Boom, J.J., Havekes, L.M. , Reduced levels of cholesterol, phospholipids, and fatty acids in cerebrospinal fluid of Alzheimer disease patients are not related to apolipoprotein E4, Alzheimer Dis Assoc Disord, vol. 12, no. 3, pp. 198-203.

Betancur, C., Cabrera, R., de Kloet, E.R., Pelaprat, D., Rostene, W. , Role of endogenous neurotensin in the behavioral and neuroendocrine effects of cocaine, Neuropsychopharmacology, vol. 19, no. 4, pp. 322-32.

Schaaf, M.J., de Jong, J., de Kloet, E.R., Vreugdenhil, E. , Downregulation of BDNF mRNA and protein in the rat hippocampus by corticosterone, Brain Res, vol. 813, no. 1, pp. 112-120.

Oitzl, M.S., Fluttert, M.F., de Kloet, E.R. , Acute blockade of hippocampal glucocorticoid receptors facilitates spatial learning in rats, Brain Res, vol. 797, no. 1, pp. 159-162.

Meijer, O.C., Kortekaas, R., Oitzl, M.S., de Kloet, E.R. , Acute rise in corticosterone facilitates 5-HT(1A) receptor-mediated behavioural responses, Eur J Pharmacol, vol. 351, no. 1, pp. 7-14.

Visser, J., van Boxel-Dezaire, A., Methorst, D., Brunt, T., de Kloet, E.R., Nagelkerken, L. , Differential regulation of interleukin-10 (IL-10) and IL-12 by glucocorticoids in vitro, Blood, vol. 91, no. 11, pp. 4255-4264.

De Kloet, E.R., Vreugdenhil, E., Oitzl, M.S., Joels, M. , Brain corticosteroid receptor balance in health and disease, Endocr Rev, vol. 19, no. 3, pp. 269-301.

van Oers, H.J., de Kloet, E.R., Li, C., Levine, S. , The ontogeny of glucocorticoid negative feedback: influence of maternal deprivation, Endocrinology, vol. 139, no. 6, pp. 2838-2846.

Sibug, R.M., Compaan, J.C., Meijer, O.C., Van der Gugten, J., Olivier, B., De Kloet, E.R. , Flesinoxan treatment reduces 5-HT1A receptor mRNA in the dentate gyrus independently of high plasma corticosterone levels, Eur J Pharmacol, vol. 353, no. 2-3, pp. 207-14.

Griep, E.N., Boersma, J.W., Lentjes, E.G., Prins, A.P., van der Korst, J.K., de Kloet, E.R. , Function of the hypothalamic-pituitary-adrenal axis in patients with fibromyalgia and low back pain, J Rheumatol, vol. 25, no. 7, pp. 1374-1381.

Visser, J., Blauw, B., Hinloopen, B., Brommer, E., de Kloet, E.R., Kluft, C., Nagelkerken, L. , CD4 T lymphocytes from patients with chronic fatigue syndrome have decreased interferon-gamma production and increased sensitivity to dexamethasone, J Infect Dis, vol. 177, no. 2, pp. 451-454.

Gomez, F., De Kloet, E.R., Armario, A. , Glucocorticoid negative feedback on the HPA axis in five inbred rat strains, Am J Physiol Regul Integr Comp Physiol, vol. 274, no. 2, pp. R420-R427.

van Oers, H.J., de Kloet, E.R., Levine, S. , Early vs. late maternal deprivation differentially alters the endocrine and hypothalamic responses to stress, Brain Res Dev Brain Res, vol. 111, no. 2, pp. 245-252.

van Oers, H.J., de Kloet, E.R., Whelan, T., Levine, S. , Maternal deprivation effect on the infant's neural stress markers is reversed by tactile stimulation and feeding but not by suppressing corticosterone, J Neurosci, vol. 18, no. 23, pp. 10171-10179.

Oitzl, M.S., Fluttert, M.F., Sutanto, W., de Kloet, E.R. , Continuous blockade of brain glucocorticoid receptors facilitates spatial learning and memory in rats, Eur J Neurosci, vol. 10, no. 12, pp. 3759-3766.

Grillo, C.A., Saravia, F., Ferrini, M., Piroli, G., Roig, P., Garcia, S. I, de Kloet, E.R., De Nicola, A.F. , Increased expression of magnocellular vasopressin mRNA in rats with deoxycorticosterone-acetate induced salt appetite, Neuroendocrinology, vol. 68, no. 2, pp. 105-115.

Meijer, O.C., de Lange, E.C., Breimer, D.D., de Boer, A.G., Workel, J.O., de Kloet, E.R. , Penetration of dexamethasone into brain glucocorticoid targets is enhanced in mdr1A P-glycoprotein knockout mice, Endocrinology, vol. 139, no. 4, pp. 1789-1793.

De Nicola, A.F., Ferrini, M., Gonzalez, S.L., Gonzalez Deniselle, M.C., Grillo, C.A., Piroli, G., Saravia, F., de Kloet, E.R. , Regulation of gene expression by corticoid hormones in the brain and spinal cord, J Steroid Biochem Mol Biol, vol. 65, no. 1-6, pp. 253-272.

Vreugdenhil, E., de Kloet, E.R. , Corticosteroid hormones and neuronal vulnerability: Towards identification of candidate vulnerability genes, Prog Brain Res, vol. 117: Elsevier, pp. 9-22.

Meijer, O.C., de Kloet, E.R. , Corticosterone and serotonergic neurotransmission in the hippocampus: functional implications of central corticosteroid receptor diversity, Crit Rev Neurobiol, vol. 12, no. 1-2, pp. 1-20.

Vreugdenhil, E., de Jong, J., De Kloet, E.R., Datson, N.A. , Differential display, serial analysis of gem expression and corticosteroid actions in brain, Eur J Neurosci, vol. 10, pp. 265-265.

Rostene, W., Nicot, A., Scarceriaux, V., De Kloet, E.R., P‚laprat, D., B‚rod, A. , Interaction between glucocorticoids and neurotensin in normal and stress responses, New Frontiers in Stress Research; Modulation of Brain Function, Amsterdam, Harwood Academic Publishers, pp. 83-94.

Muler, M., van der Boom, H., Haasdijk, E.D., Dalm, S., De Kloet, E.R., Havekes, L.M., Holstege, J.C., Jaarsma, D. , Increased apolipoprotein E expression in a transgenic mouse model for amyotrophic lateral sclerosis, Eur J Neurosci, vol. 10, pp. 374-374.

Levy, A., Grauer, E., Ben-Nathan, B., De Kloet, E.R. , New frontiers in stress research: modulation of brain function, , no. xix, 299 p, Australia, Harwood Academic.

Grootendorst, J., Dalm, S., De Kloet, E.R., Oitzl, M.S. , Spatial learning of apolipoprotein E knockout mice in a water maze: Influence of repeated exposure to rats, Brain Res, vol. 809, no. 1, pp. A29-A29.

1997

Meijer, O.C., Van Oosten, R.V., De Kloet, E.R. , Elevated basal trough levels of corticosterone suppress hippocampal 5-hydroxytryptamine(1A) receptor expression in adrenally intact rats: implication for the pathogenesis of depression, Neuroscience, vol. 80, no. 2, pp. 419-426.

De Kloet, E.R. , Why Dexamethasone Poorly Penetrates in Brain, Stress, vol. 2, no. 1, pp. 13-20.

Karst, H., de Kloet, E.R., Joels, M. , Effect of ORG 34116, a corticosteroid receptor antagonist, on hippocampal Ca2+ currents, Eur J Pharmacol, vol. 339, no. 1, pp. 17-26.

Workel, J.O., Oitzl, M.S., Ledeboer, A., De Kloet, E.R. , The Brown Norway rat displays enhanced stress-induced ACTH reactivity at day 18 after 24-h maternal deprivation at day 3, Brain Res Dev Brain Res, vol. 103, no. 2, pp. 199-203.

Karst, H., Bosma, A., Hendriksen, E., Kamphuis, W., de Kloet, E.R., Joels, M. , Effect of adrenalectomy in kindled rats, Neuroendocrinology, vol. 66, no. 5, pp. 348-359.

van Haarst, A.D., Oitzl, M.S., de Kloet, E.R. , Facilitation of feedback inhibition through blockade of glucocorticoid receptors in the hippocampus, Neurochem Res, vol. 22, no. 11, pp. 1323-1328.

Lentjes, E.G., Griep, E.N., Boersma, J.W., Romijn, F.P., de Kloet, E.R. , Glucocorticoid receptors, fibromyalgia and low back pain, Psychoneuroendocrinology, vol. 22, no. 8, pp. 603-614.

Oitzl, M.S., de Kloet, E.R., Joels, M., Schmid, W., Cole, T.J. , Spatial learning deficits in mice with a targeted glucocorticoid receptor gene disruption, Eur J Neurosci, vol. 9, no. 11, pp. 2284-2296.

Bhatnagar, M., Cintra, A., Chadi, G., Lindberg, J., Oitzl, M.S., De Kloet, E.R., Moller, A., Agnati, L.F., Fuxe, K. , Neurochemical changes in the hippocampus of the brown Norway rat during aging, Neurobiol Aging, vol. 18, no. 3, pp. 319-327.

Schaaf, M.J., Hoetelmans, R.W., de Kloet, E.R., Vreugdenhil, E. , Corticosterone regulates expression of BDNF and trkB but not NT-3 and trkC mRNA in the rat hippocampus, J Neurosci Res, vol. 48, no. 4, pp. 334-41.

Oitzl, M.S., Mulder, M., Lucassen, P.J., Havekes, L.M., Grootendorst, J., de Kloet, E.R. , Severe learning deficits in apolipoprotein E-knockout mice in a water maze task, Brain Res, vol. 752, no. 1-2, pp. 189-196.

Meijer, O.C., Cole, T.J., Schmid, W., Schutz, G., Joels, M., De Kloet, E.R. , Regulation of hippocampal 5-HT1A receptor mRNA and binding in transgenic mice with a targeted disruption of the glucocorticoid receptor, Brain Res Mol Brain Res, vol. 46, no. 1-2, pp. 290-296.

Krugers, H.J., Mulder, M., Korf, J., Havekes, L., de Kloet, E.R., Joels, M. , Altered synaptic plasticity in hippocampal CA1 area of apolipoprotein E deficient mice, Neuroreport, vol. 8, no. 11, pp. 2505-2510.

Szuran, T.F., van Haarst, A.D., de Kloet, E.R., Pliska, V. , Steroid receptors in the rat hippocampus: a note to the methodology of their binding assay, J Recept Signal Transduct Res, vol. 17, no. 1-3, pp. 337-354.

De Kloet, E.R., Vreugdenhil, E., Oitzl, M.S., Joels, M. , Glucocorticoid feedback resistance, Trends Endocrinol Metab, vol. 8, no. 1, pp. 26-33.

Ferrini, M.G., Grillo, C.A., Piroli, G., de Kloet, E.R., De Nicola, A.F. , Sex difference in glucocorticoid regulation of vasopressin mRNA in the paraventricular hypothalamic nucleus, Cell Mol Neurobiol, vol. 17, no. 6, pp. 671-686.

van Oers, H.J., de Kloet, E.R., Levine, S. , Persistent, but Paradoxical, Effects on HPA Regulation of Infants Maternally Deprived at Different Ages, Stress, vol. 1, no. 4, pp. 249-262.

Nicot, A., Rowe, W.B., De Kloet, E.R., Betancur, C., Jessop, D.S., Lightman, S.L., Quirion, R., Rostene, W., Berod, A. , Endogenous neurotensin regulates hypothalamic-pituitary-adrenal axis activity and peptidergic neurons in the rat hypothalamic paraventricular nucleus, J Neuroendocrinol, vol. 9, no. 4, pp. 263-269.

Oitzl, M.S., van Haarst, A.D., de Kloet, E.R. , Behavioral and neuroendocrine responses controlled by the concerted action of central mineralocorticoid (MRS) and glucocorticoid receptors (GRS), Psychoneuroendocrinology, vol. 22, no. Suppl-1, pp. S87-S93.

Joels, M., Karten, Y., Hesen, W., de Kloet, E.R. , Corticosteroid effects on electrical properties of brain cells: temporal aspects and role of antiglucocorticoids, Psychoneuroendocrinology, vol. 22 Suppl 1, pp. S81-S86.

De Kloet, E.R. , Early experience, genotype and vulnerability to depressive illness, De pathogenese van stoornissen in de affectregulatie; een psychobiologische integratie. Boerhaave course, pp. 53-59.

Zant, J.L., Mooij, A., Griep, E.N., Boersma, J.W., De Kloet, E.R. , Fibromyalgia in relation to the process of early attachment, Nederlands Tijdschrift voor Pijn en Pijnbestrijding (NTPP), vol. 17, no. 2, pp. 25-27.

de Rijk, R.H., Sternberg, E.M., De Kloet, E.R. , Glucocorticoid receptor function in health and disease, Current Opinion in Endocrinology & Diabetes, vol. 4, no. 3, pp. 185-193.

De Kloet, E.R., Oitzl, M.S. , Special issue dedicated to Dr. Bruce S. McEwen - Preface, Neurochem Res, vol. 22, no. 11, pp. 1319-1320.

De Kloet, E.R. , Toekomstperspectieven in de behandeling van de ziekte van Alzheimer, Folia Pharmaceutica, vol. 9, pp. 21-31.

1996

Vreugdenhil, E., de Jong, J., Schaaf, M.J., Meijer, O.C., Busscher, J., Vuijst, C., de Kloet, E.R. , Molecular dissection of corticosteroid action in the rat hippocampus. Application of the differential display techniques, J Mol Neurosci, vol. 7, no. 2, pp. 135-146.

De Kloet, E.R., Korte, S.M., Rots, N.Y., Kruk, M.R. , Stress hormones, genotype, and brain organization. Implications for aggression, Ann N Y Acad Sci, vol. 794, pp. 179-91.

Korte, S.M., Meijer, O.C., de Kloet, E.R., Buwalda, B., Keijser, J., Sluyter, F., van Oortmerssen, G., Bohus, B. , Enhanced 5-HT1A receptor expression in forebrain regions of aggressive house mice, Brain Res, vol. 736, no. 1-2, pp. 338-343.

Hesen, W., Karst, H., Meijer, O.C., Cole, T.J., Schmid, W., de Kloet, E.R., Schutz, G., Joels, M. , Hippocampal cell responses in mice with a targeted glucocorticoid receptor gene disruption, J Neurosci, vol. 16, no. 21, pp. 6766-6774.

Korte-Bouws, G.A., Korte, S.M., De Kloet, E.R., Bohus, B. , Blockade of corticosterone synthesis reduces serotonin turnover in the dorsal hippocampus of the rat as measured by microdialysis, J Neuroendocrinol, vol. 8, no. 11, pp. 877-881.

van Haarst, A.D., Oitzl, M.S., Workel, J.O., de Kloet, E.R. , Chronic brain glucocorticoid receptor blockade enhances the rise in circadian and stress-induced pituitary-adrenal activity, Endocrinology, vol. 137, no. 11, pp. 4935-4943.

Rots, N.Y., Cools, A.R., Oitzl, M.S., de Jong, J., Sutanto, W., de Kloet, E.R. , Divergent prolactin and pituitary-adrenal activity in rats selectively bred for different dopamine responsiveness, Endocrinology, vol. 137, no. 5, pp. 1678-1686.

Korte, S.M., Korte-Bouws, G.A., Koob, G.F., De Kloet, E.R., Bohus, B. , Mineralocorticoid and glucocorticoid receptor antagonists in animal models of anxiety, Pharmacol Biochem Behav, vol. 54, no. 1, pp. 261-267.

de Kloet, E.R., Rots, N.Y., Cools, A.R. , Brain-corticosteroid hormone dialogue: slow and persistent, Cell Mol Neurobiol, vol. 16, no. 3, pp. 345-356.

Vreugdenhil, E., de Jong, J., Busscher, J.S., de Kloet, E.R. , Kainic acid-induced gene expression in the rat hippocampus is severely affected by adrenalectomy, Neurosci Lett, vol. 212, no. 2, pp. 75-78.

Hornsby, C.D., Grootendorst, J., de Kloet, E.R. , Dexamethasone Does Not Prevent Seven-Day ADX-Induced Apoptosis in the Dentate Gyrus of the Rat Hippocampus, Stress, vol. 1, no. 1, pp. 51-64.

Rots, N.Y., de Jong, J., Workel, J.O., Levine, S., Cools, A.R., De Kloet, E.R. , Neonatal maternally deprived rats have as adults elevated basal pituitary-adrenal activity and enhanced susceptibility to apomorphine, J Neuroendocrinol, vol. 8, no. 7, pp. 501-506.

Rots, N.Y., Cools, A.R., Berod, A., Voorn, P., Rostene, W., de Kloet, E.R. , Rats bred for enhanced apomorphine susceptibility have elevated tyrosine hydroxylase mRNA and dopamine D2-receptor binding sites in nigrostriatal and tuberoinfundibular dopamine systems, Brain Res, vol. 710, no. 1-2, pp. 189-196.

Korte, S.M., Buwalda, B., De Kloet, E.R., Bohus, B. , Adrenaline release by the 5-HT1A receptor agonist 8-OH-DPAT is partly responsible for pituitary activation, Eur J Pharmacol, vol. 309, no. 3, pp. 281-286.

van Haarst, A.D., Welberg, L.A., Sutanto, W., Oitzl, M.S., de Kloet, E.R. , 11 beta-Hydroxysteroid dehydrogenase activity in the hippocampus: implications for in vivo corticosterone receptor binding and cell nuclear retention, J Neuroendocrinol, vol. 8, no. 8, pp. 595-600.

Rots, N.Y., Workel, J., Oitzl, M.S., Berod, A., Rostene, W., Cools, A.R., De Kloet, E.R. , Development of divergence in dopamine responsiveness in genetically selected rat lines is preceded by changes in pituitary-adrenal activity, Brain Res Dev Brain Res, vol. 92, no. 2, pp. 164-171.

Sutanto, W., Rosenfeld, P., de Kloet, E.R., Levine, S. , Long-term effects of neonatal maternal deprivation and ACTH on hippocampal mineralocorticoid and glucocorticoid receptors, Brain Res Dev Brain Res, vol. 92, no. 2, pp. 156-163.

Korte, S.M., De Kloet, E.R., Buwalda, B., Bouman, S.D., Bohus, B. , Antisense to the glucocorticoid receptor in hippocampal dentate gyrus reduces immobility in forced swim test, Eur J Pharmacol, vol. 301, no. 1-3, pp. 19-25.

Gomez, F., Lahmame, A., de Kloet, E.R., Armario, A. , Hypothalamic-pituitary-adrenal response to chronic stress in five inbred rat strains: differential responses are mainly located at the adrenocortical level, Neuroendocrinology, vol. 63, no. 4, pp. 327-337.

van Steensel, B., van Binnendijk, E.P., Hornsby, C.D., van der Voort, H.T., Krozowski, Z.S., de Kloet, E.R., van Driel, R. , Partial colocalization of glucocorticoid and mineralocorticoid receptors in discrete compartments in nuclei of rat hippocampus neurons, J Cell Sci, vol. 109, no. 4, pp. 787-792.

De Kloet, E.R. , Corticosteroiden, Farmacologie, Utrecht, Wetenschappelijke Uitgeverij Bunge, pp. 175-184.

De Kloet, E.R., Joels, M. , Corticosteroid hormones in neuroprotection and brain damage, Current Opinion in Endocrinology & Diabetes, vol. 3, no. 2, pp. 184-192.

De Kloet, E.R. , Functional implications of brain corticosteroid receptor diversity, Medicina-Buenos Aires, vol. 56, no. 5, pp. 633-633.

De Kloet, E.R. , Hormones, stress and cognitive failure, Medicina-Buenos Aires, vol. 56, no. 5, pp. 629-629.

De Kloet, E.R. , Toekomstperspectieven in de behandeling van de Ziekte van Alzheimer, De Ziekte van Alzheimer; Boerhaave course, pp. 101-115.

1995

van Steensel, B., Brink, M., van der Meulen, K., van Binnendijk, E.P., Wansink, D.G., de Jong, L., de Kloet, E.R., van Driel, R. , Localization of the glucocorticoid receptor in discrete clusters in the cell nucleus, J Cell Sci, vol. 108, no. 9, pp. 3003-3011.

de Kloet, E.R. , Steroids, stability and stress, Front Neuroendocrinol, vol. 16, no. 4, pp. 416-425.

Sutanto, W., de Kloet, E.R. , Corticosteroid receptor antagonists: a current perspective, Pharm World Sci, vol. 17, no. 2, pp. 31-41.

Van Eekelen, J.A., Oitzl, M.S., De Kloet, E.R. , Adrenocortical hyporesponsiveness and glucocorticoid feedback resistance in old male brown Norway rats, J Gerontol A Biol Sci Med Sci, vol. 50A, no. 2, pp. B83-B89.

Joels, M., Hesen, W., de Kloet, E.R. , Long-term control of neuronal excitability by corticosteroid hormones, J Steroid Biochem Mol Biol, vol. 53, no. 1-6, pp. 315-323.

Korte, S.M., Buwalda, B., Meijer, O.C., De Kloet, E.R., Bohus, B. , Socially defeated male rats display a blunted adrenocortical response to a low dose of 8-OH-DPAT, Eur J Pharmacol, vol. 272, no. 1, pp. 45-50.

Rots, N.Y., Cools, A.R., de Jong, J., De Kloet, E.R. , Corticosteroid feedback resistance in rats genetically selected for increased dopamine responsiveness, J Neuroendocrinol, vol. 7, no. 2, pp. 153-161.

Vallee, S.M., Grillo, C.A., Gonzalez, S., Cosen-Binker, L., de Kloet, E.R., McEwen, B.S., De Nicola, A.F. , Further studies in deoxycorticosterone acetate treated rats: brain content of mineralocorticoid and glucocorticoid receptors and effect of steroid antagonists on salt intake, Neuroendocrinology, vol. 61, no. 2, pp. 117-124.

Carey, M.P., Deterd, C.H., de Koning, J., Helmerhorst, F., de Kloet, E.R. , The influence of ovarian steroids on hypothalamic-pituitary-adrenal regulation in the female rat, J Endocrinol, vol. 144, no. 2, pp. 311-321.

Meijer, O.C., de Kloet, E.R. , A role for the mineralocorticoid receptor in a rapid and transient suppression of hippocampal 5-HT1A receptor mRNA by corticosterone, J Neuroendocrinol, vol. 7, no. 8, pp. 653-657.

Korte, S.M., de Boer, S.F., de Kloet, E.R., Bohus, B. , Anxiolytic-like effects of selective mineralocorticoid and glucocorticoid antagonists on fear-enhanced behavior in the elevated plus-maze, Psychoneuroendocrinology, vol. 20, no. 4, pp. 385-394.

Joels, M., De Kloet, E.R. , Corticosteroid Hormones - Endocrine Messengers in the Brain, News Physiol Sci, vol. 10, no. 2, pp. 71-76.

Oitzl, M.S., van Haarst, A.D., Sutanto, W., de Kloet, E.R. , Corticosterone, brain mineralocorticoid receptors (MRs) and the activity of the hypothalamic-pituitary-adrenal (HPA) axis: the Lewis rat as an example of increased central MR capacity and a hyporesponsive HPA axis, Psychoneuroendocrinology, vol. 20, no. 6, pp. 655-675.

De Kloet, E.R., Wiegant, V.M. , Stress and Neuropathology, Boerhaave cursus, no. viii, 153 , Leiden, Boerhaave Commissie voor Postacademisch Onderwijs in de Geneeskunde, Rijksuniversiteit Leiden, pp. 7-22.

Rostene, W., Sarrieau, A., Nicot, A., Scarceriaux, V., Betancur, C., Gully, D., Meaney, M., Rowe, W., De Kloet, E.R., Pelaprat, D. , Steroid effects on brain functions: an example of the action of glucocorticoids on central dopaminergic and neurotensinergic systems, J Psychiatry Neurosci, vol. 20, no. 5, pp. 349-356.

van Steensel, B., Binnendijk, E., van der Meulen, K., Jenster, G., Damm, K., Hornsby, C.D., Wansink, D.G., De Kloet, E.R., vanDriel, R. , Steroid-Receptors, Transcription and Nuclear Architecture, J Cellular Biochemistry, pp. 141-141.

Visser, G.M., Krugers, H.J., Luurtsema, G., Van Waarde, A., Elsinga, P.H., De Kloet, E.R., Groen, M.B., Bohus, B., Go, K.G., Paans, A.M.J., Korf, J., Vaalburg, W. , Synthesis and Organ Distribution of [F-18]Fluoro-Org-6141 in the Rat - A Potential Glucocorticoid Receptor-Ligand for Positron Emission Tomography, Nuclear Medicine and Biology, vol. 22, no. 7, pp. 915-920.

1994

Sutanto, W., de Kloet, E.R. , The use of various animal models in the study of stress and stress-related phenomena, Lab Anim, vol. 28, no. 4, pp. 293-306.

Meijer, O.C., Oitzl, M.S., de Kloet, E.R. , Adrenalectomy leads to a different responsiveness to 8-OH-DPAT in a water-maze learning task, Ann N Y Acad Sci, vol. 746, pp. 408-10.

de Kloet, E.R., Rots, N.Y., van den Berg, D.T., Oitzl, M.S. , Brain mineralocorticoid receptor function, Ann N Y Acad Sci, vol. 746, pp. 8-20; discussion 20-1, 64-7.

Hornsby, C.D., de Kloet, E.R. , Dexamethasone does not prevent apoptosis in the hippocampus of the rat, Ann N Y Acad Sci, vol. 746, pp. 470-2.

Carey, M.P., de Kloet, E.R. , Interaction of progesterone with the hippocampal mineralocorticoid receptor, Ann N Y Acad Sci, vol. 746, pp. 434-7.

Korte, S.M., Buwalda, B., de Kloet, E.R., Bohus, B. , Social defeat impairs plasma corticosterone response to the 5-HT1A agonist 8-OH-DPAT in the rat, Ann N Y Acad Sci, vol. 746, pp. 426-8.

Cirulli, F., van Oers, H., De Kloet, E.R., Levine, S. , Differential influence of corticosterone and dexamethasone on schedule-induced polydipsia in adrenalectomized rats, Behav Brain Res, vol. 65, no. 1, pp. 33-9.

Schobitz, B., De Kloet, E.R., Holsboer, F. , Gene expression and function of interleukin 1, interleukin 6 and tumor necrosis factor in the brain, Prog Neurobiol, vol. 44, no. 4, pp. 397-432.

Griep, E.N., Boersma, J.W., de Kloet, E.R. , Pituitary release of growth hormone and prolactin in the primary fibromyalgia syndrome, J Rheumatol, vol. 21, no. 11, pp. 2125-30.

Joels, M., de Kloet, E.R. , Mineralocorticoid and glucocorticoid receptors in the brain. Implications for ion permeability and transmitter systems, Prog Neurobiol, vol. 43, no. 1, pp. 1-36.

Nicot, A., Berod, A., Gully, D., Rowe, W., Quirion, R., de Kloet, E.R., Rostene, W. , Blockade of neurotensin binding in the rat hypothalamus and of the central action of neurotensin on the hypothalamic-pituitary-adrenal axis with non-peptide receptor antagonists, Neuroendocrinology, vol. 59, no. 6, pp. 572-578.

Joels, M., Hesen, W., Karst, H., de Kloet, E.R. , Steroids and electrical activity in the brain, J Steroid Biochem Mol Biol, vol. 49, no. 4-6, pp. 391-398.

Oitzl, M.S., Fluttert, M.F., de Kloet, E.R. , The effect of corticosterone on reactivity to spatial novelty is mediated by central mineralocorticosteroid receptors, Eur J Neurosci, vol. 6, no. 7, pp. 1072-1079.

Meijer, O.C., de Kloet, E.R. , Corticosterone suppresses the expression of 5-HT1A receptor mRNA in rat dentate gyrus, Eur J Pharmacol, vol. 266, no. 3, pp. 255-261.

Van den Berg, D.T., de Kloet, E.R., de Jong, W. , Central effects of mineralocorticoid antagonist RU-28318 on blood pressure of DOCA-salt hypertensive rats, Am J Physiol Endocrinol Metab, vol. 267, no. 6, pp. E927-E933.

Wiegers, G.J., Reul, J.M., Holsboer, F., de Kloet, E.R. , Enhancement of rat splenic lymphocyte mitogenesis after short term preexposure to corticosteroids in vitro, Endocrinology, vol. 135, no. 6, pp. 2351-2357.

Van den Berg, D.T., de Jong, W., de Kloet, E.R. , Mineralocorticoid antagonist inhibits stress-induced blood pressure response after repeated daily warming, Am J Physiol Endocrinol Metab, vol. 267, no. 6, pp. E921-E926.

Schobitz, B., Sutanto, W., Carey, M.P., Holsboer, F., de Kloet, E.R. , Endotoxin and interleukin 1 decrease the affinity of hippocampal mineralocorticoid (type I) receptor in parallel to activation of the hypothalamic-pituitary-adrenal axis, Neuroendocrinology, vol. 60, no. 2, pp. 124-133.

Schobitz, B., Holsboer, F., Sutanto, W., Gross, G., Schonbaum, E., de Kloet, E.R. , Corticosterone modulates interleukin-evoked fever in the rat, Neuroendocrinology, vol. 59, no. 4, pp. 387-395.

De Kloet, E.R., Azmitia, E.C., Landfield, P.W. , Brain corticosteroid receptors, studies on the mechanism, function, and neurotoxicity of corticosteroid action, Ann N Y Acad Sci, no. xi, 499 p, New York, N.Y, New York Academy of Sciences.

Cintra, A., Lindberg, J., Chadi, G., Tinner, B., Moller, A., Gustafsson, J.A., De Kloet, E.R., Oitzl, M.S., Nishikawa, K., Agnati, L.F. , Basic fibroblast growth factor and steroid receptors in the aging hippocampus of the brown Norway rat: immunocytochemical analysis in combination with stereology, Neurochem Int, vol. 25, no. 1, pp. 39-45.

De Kloet, E.R., Oitzl, M.S., Schobitz, B. , Cytokines and the brain corticosteroid receptor balance: relevance to pathophysiology of neuroendocrine-immune communication, Psychoneuroendocrinology, vol. 19, no. 2, pp. 121-134.

Schobitz, B., Holsboer, F., De Kloet, E.R. , Cytokines in the Healthy and Diseased Brain, News Physiol Sci, vol. 9, no. 3, pp. 138-142.

De Kloet, E.R., Sutanto, W. , Methods in neurosciences, , vol. Neurobiolo.

De Kloet, E.R., Sutanto, W. , Neurobiology of steroids, Methods in neurosciences, no. xviii, 552, San Diego, Academic Press.

Madsen, C.S., Brooks, J.E., De Kloet, E., de Kloet, S.R. , Sequence conservation of an avian centromeric repeated DNA component, Genome, vol. 37, no. 3, pp. 351-355.

van Steensel, B., Jenster, G., Wansink, D.G., Damm, K., De Kloet, E.R., van Driel, R. , Steroid-Receptors, Transcription and Nuclear Architecture, J Cellular Biochemistry, vol. 56, no. Suppl 18C, pp. 96-96.

1993

Joels, M., de Kloet, E.R. , Corticosteroid actions on amino acid-mediated transmission in rat CA1 hippocampal cells, J Neurosci, vol. 13, no. 9, pp. 4082-90.

Schobitz, B., de Kloet, E.R., Sutanto, W., Holsboer, F. , Cellular localization of interleukin 6 mRNA and interleukin 6 receptor mRNA in rat brain, Eur J Neurosci, vol. 5, no. 11, pp. 1426-1435.

Van Erp, A.M., Kruk, M.R., De Kloet, E.R. , Induction of grooming in resting rats by intracerebroventricular oxytocin but not by adrenocorticotropic hormone-(1-24) and alpha-melanocyte-stimulating hormone, Eur J Pharmacol, vol. 232, no. 2-3, pp. 217-21.

Griep, E.N., Boersma, J.W., de Kloet, E.R. , Altered reactivity of the hypothalamic-pituitary-adrenal axis in the primary fibromyalgia syndrome, J Rheumatol, vol. 20, no. 3, pp. 469-74.

Oitzl, M.S., van Oers, H., Schobitz, B., de Kloet, E.R. , Interleukin-1 beta, but not interleukin-6, impairs spatial navigation learning, Brain Res, vol. 613, no. 1, pp. 160-163.

van Dijken, H.H., de Goeij, D.C., Sutanto, W., Mos, J., de Kloet, E.R., Tilders, F.J. , Short inescapable stress produces long-lasting changes in the brain-pituitary-adrenal axis of adult male rats, Neuroendocrinology, vol. 58, no. 1, pp. 57-64.

Rothuizen, J., Reul, J.M., van Sluijs, F.J., Mol, J.A., Rijnberk, A., de Kloet, E.R. , Increased neuroendocrine reactivity and decreased brain mineralocorticoid receptor-binding capacity in aged dogs, Endocrinology, vol. 132, no. 1, pp. 161-168.

de Kloet, E.R., Sutanto, W., van den Berg, D.T., Carey, M.P., van Haarst, A.D., Hornsby, C.D., Meijer, O.C., Rots, N.Y., Oitzl, M.S. , Brain mineralocorticoid receptor diversity: functional implications, J Steroid Biochem Mol Biol, vol. 47, no. 1-6, pp. 183-190.

Wiegers, G.J., Croiset, G., Reul, J.M., Holsboer, F., de Kloet, E.R. , Differential effects of corticosteroids on rat peripheral blood T-lymphocyte mitogenesis in vivo and in vitro, Am J Physiol Endocrinol Metab, vol. 265, no. 6 Pt 1, pp. E825-E830.

de Kloet, E.R., Oitzl, M.S., Joels, M. , Functional implications of brain corticosteroid receptor diversity, Cell Mol Neurobiol, vol. 13, no. 4, pp. 433-455.

Rosenfeld, P., van Eekelen, J.A., Levine, S., de Kloet, E.R. , Ontogeny of corticosteroid receptors in the brain, Cell Mol Neurobiol, vol. 13, no. 4, pp. 295-319.

de Kloet, E.R., Elands, J., Voorhuis, D.A. , Implication of central neurohypophyseal hormone receptor-mediated action in timing of reproductive events: evidence from novel observations on the effect of a vasotocin analogue on singing behaviour of the canary, Regul Pept, vol. 45, no. 1-2, pp. 85-89.

Schobitz, B., Van Den Dobbelsteen, M., Holsboer, F., Sutanto, W., De Kloet, E.R. , Regulation of interleukin 6 gene expression in rat, Endocrinology, vol. 132, no. 4, pp. 1569-1576.

Cools, A.R., Rots, N.Y., Ellenbroek, B., de Kloet, E.R. , Bimodal shape of individual variation in behavior of Wistar rats: the overall outcome of a fundamentally different make-up and reactivity of the brain, the endocrinological and the immunological system, Neuropsychobiology, vol. 28, no. 1-2, pp. 100-105.

Oitzl, M.S., Sutanto, W., Houtzager, S., De Kloet, E.R. , Brain Corticosteroid Receptors and Stress Responsiveness in the Lewis Rat, Neuropsychopharmacology, vol. 9, no. 2, pp. S171-S172.

Griep, E.N., Boersma, J.W., de Kloet, E.R. , Evidence for Neuroendoncrine Disturbance Following Physical Exercise in Primary Fibromyalgia Syndrome, J Musculoskeletal Pain, vol. 1, no. 3-4, pp. 217-222.

De Kloet, E.R., Oitzl, M.S., Joels, M. , Mineralo (Type-1) and Glucocorticoid (Type-2) Receptors in Brain - Behavioral Biochemical and Electrophysiological Studies, Neuropsychopharmacology, vol. 9, no. 2, pp. S4-S4.

van Haarst, A.D., Oitzl, M.S., De Kloet, E.R. , Nonacute Effects of Anti-Glucocorticoid Injection Into the Rat Cerebroventricular System, Neuropsychopharmacology, vol. 9, no. 2, pp. S139-S140.

Sutanto, W., De Kloet, E.R. , The role of GABA in the regulation of the stress response, Stress: from Synapse to Syndrome, London, Academic Press Ltd., pp. 333-354.

1992

Voorhuis, T.A., de Kloet, E.R. , Immunoreactive vasotocin in the zebra finch brain (Taeniopygia guttata), Brain Res Dev Brain Res, vol. 69, no. 1, pp. 1-10.

Schobitz, B., Holsboer, F., Kikkert, R., Sutanto, W., De Kloet, E.R. , Peripheral and central regulation of IL-6 gene expression in endotoxin-treated rats, Endocr Regul, vol. 26, no. 3, pp. 103-109.

de Kloet, E.R. , Corticosteroids, stress, and aging, Ann N Y Acad Sci, vol. 663, pp. 357-71.

Schobitz, B., Voorhuis, D.A., De Kloet, E.R. , Localization of interleukin 6 mRNA and interleukin 6 receptor mRNA in rat brain, Neurosci Lett, vol. 136, no. 2, pp. 189-192.

Joels, M., De Kloet, E.R. , Coordinative mineralocorticoid and glucocorticoid receptor-mediated control of responses to serotonin in rat hippocampus, Neuroendocrinology, vol. 55, no. 3, pp. 344-350.

Langeveld, C.H., van Waas, M.P., Stoof, J.C., Sutanto, W., de Kloet, E.R., Wolbers, J.G., Heimans, J.J. , Implication of glucocorticoid receptors in the stimulation of human glioma cell proliferation by dexamethasone, J Neurosci Res, vol. 31, no. 3, pp. 524-531.

Brink, M., Humbel, B.M., De Kloet, E.R., Van Driel, R. , The unliganded glucocorticoid receptor is localized in the nucleus, not in the cytoplasm, Endocrinology, vol. 130, no. 6, pp. 3575-3581.

van Eekelen, J.A., Rots, N.Y., Sutanto, W., de Kloet, E.R. , The effect of aging on stress responsiveness and central corticosteroid receptors in the brown Norway rat, Neurobiol Aging, vol. 13, no. 1, pp. 159-170.

Joels, M., de Kloet, E.R. , Control of neuronal excitability by corticosteroid hormones, Trends Neurosci, vol. 15, no. 1, pp. 25-30.

Langeveld, C.H., Wolbers, J.G., Heimans, J.J., Stoof, J.C., de Kloet, E.R. , Hormone receptors and glioma cell growth, J Neurosurg, vol. 76, no. 1, pp. 168-168.

Oitzl, M.S., de Kloet, E.R. , Selective corticosteroid antagonists modulate specific aspects of spatial orientation learning, Behav Neurosci, vol. 106, no. 1, pp. 62-71.

De Kloet, E.R., Oitzl, M.S., Joels, M. , Corticosteroid receptor diversity in hippocampus: neuronal activity and spatial learning, Stress: Neuroendocrine and Molecular Approaches, vol. 1, New York, USA, Gordon and Breach Science Publishers SA, pp. 735-749.

Van den Berg, D.T.W.M., De Kloet, E.R., Janssen, B.J.A. , Central steroid receptor function in spontaneously hypotensive rats: effects of gluco- and mineralocorticoids, Genetics Hypertension, vol. 218: Colloque INSERM, John Libbey Eurotext Ltd, pp. 133-135.

Sutanto, W., Oitzl, M.S., Rots, N.Y., Schobitz, B., Van den Berg, D.T.W.M., van Dijken, H.H., Mos, J., Cools, A.R., Tilders, F.J., Koolhaas, J.M., De Kloet, E.R. , Corticosteroid receptor plasticity in the central nervous system of various rat models, Endocr Regul, vol. 26, no. 3, pp. 111-118.

Van Eekelen, J.A., De Kloet, E.R. , Co-localization of brain corticosteroid receptors in the rat hippocampus, Prog Histochem Cytochem, vol. 26, no. 1-4, pp. 250-258.

De Kloet, E.R., Voorhuis, T.A.M. , Neuropeptides, Steroid-Hormones, Stress and Reproduction, J Controlled Release, vol. 21, no. 1-3, pp. 105-116.

Elands, J., de Kloet, E.R., de Wied, D. , Neurohypophyseal hormone receptors: relation to behavior, Prog Brain Res, vol. 91, pp. 459-464.

McEwen, B.S., Goudsmit, E., Ravid, R., Swaab, D.F., Mirmiran, M., Kopp, N., De Kloet, E.R., Taljaard, J.J.F. , Reexamination of the Glucocorticoid Hypothesis of Stress and Aging, Prog Brain Res, vol. 93, pp. 365-383.

1991

Sijbesma, H., Schipper, J., Molewijk, H.E., Bosch, A. I, de Kloet, E.R. , 8-hydroxy-2-(di-N-propylamino)tetralin increases the activity of adenylate cyclase in the hippocampus of freely-moving rats, Neuropharmacology, vol. 30, no. 9, pp. 967-975.

van Steensel, B., van Haarst, A.D., de Kloet, E.R., van Driel, R. , Binding of corticosteroid receptors to rat hippocampus nuclear matrix, FEBS Lett, vol. 292, no. 1-2, pp. 229-231.

Eijgelshoven, M.H., De Kloet, E.R., Van den Berg, D.T., Van Giersbergen, P.L. , Activation of glucocorticoid receptors and the effect of naloxone during hemorrhagic hypotension, Eur J Pharmacol, vol. 205, no. 2, pp. 183-189.

Sutanto, W., de Kloet, E.R. , Mineralocorticoid receptor ligands: biochemical, pharmacological, and clinical aspects, Med Res Rev, vol. 11, no. 6, pp. 617-639.

Voorhuis, T.A., De Kloet, E.R., De Wied, D. , Ontogenetic and seasonal changes in immunoreactive vasotocin in the canary brain, Brain Res Dev Brain Res, vol. 61, no. 1, pp. 23-31.

van Eekelen, J.A., Bohn, M.C., de Kloet, E.R. , Postnatal ontogeny of mineralocorticoid and glucocorticoid receptor gene expression in regions of the rat tel- and diencephalon, Brain Res Dev Brain Res, vol. 61, no. 1, pp. 33-43.

Sijbesma, H., Schipper, J., de Kloet, E.R., Mos, J., van Aken, H., Olivier, B. , Postsynaptic 5-HT1 receptors and offensive aggression in rats: a combined behavioural and autoradiographic study with eltoprazine, Pharmacol Biochem Behav, vol. 38, no. 2, pp. 447-458.

Voorhuis, T.A., De Kloet, E.R., De Wied, D. , Effect of a vasotocin analog on singing behavior in the canary, Horm Behav, vol. 25, no. 4, pp. 549-559.

Sijbesma, H., Schipper, J., Cornelissen, J.C., de Kloet, E.R. , Species differences in the distribution of central 5-HT1 binding sites: a comparative autoradiographic study between rat and guinea pig, Brain Res, vol. 555, no. 2, pp. 295-304.

Joels, M., Hesen, W., de Kloet, E.R. , Mineralocorticoid hormones suppress serotonin-induced hyperpolarization of rat hippocampal CA1 neurons, J Neurosci, vol. 11, no. 8, pp. 2288-2294.

Reul, J.M.H.M., Rothuizen, J., De Kloet, E.R. , Aging and the canine hypothalamo-pituitary-adrenocortical (HPA) axis, Biol Psychiatry: Excerpta Medica (Int. Congr. Series 968), pp. 217-221.

Reul, J.M., Rothuizen, J., de Kloet, E.R. , Age-related changes in the dog hypothalamic-pituitary-adrenocortical system: neuroendocrine activity and corticosteroid receptors, J Steroid Biochem Mol Biol, vol. 40, no. 1-3, pp. 63-69.

Rothuizen, J., Reul, J.M., Rijnberk, A., Mol, J.A., de Kloet, E.R. , Aging and the hypothalamus-pituitary-adrenocortical axis, with special reference to the dog, Acta Endocrinologica, vol. 125, no. 6, Suppl 1, pp. 73-76.

De Kloet, E.R., Joels, M. , Brain Corticosteroid Receptors and Neurotransmission, Volume Transmission in the Brain: Novel Mechanisms for Neural Transmissio, New York, Raven Press, pp. 213-225.

De Kloet, E.R. , Brain Corticosteroid Receptor Balance and Homeostatic Control, Front Neuroendocrinol, vol. 12, no. 2, pp. 95-164.

van Eekelen, J.A., Rots, N.Y., Sutanto, W., Oitzl, M.S., de Kloet, E.R. , Brain corticosteroid receptor gene expression and neuroendocrine dynamics during aging, J Steroid Biochem Mol Biol, vol. 40, no. 4-6, pp. 679-683.

De Kloet, E.R. , Equilibrium in a changing world. (Oration), , Leiden, University Leiden.

Van Giersbergen, P.L.M., van den Berg, M.H., Eijgelshoven, M.H., Cox-van Put, J., Van den Berg, D.T.W.M., De Kloet, E.R., De Jong, W. , Endogenous opioids glucocorticoids and shock: specificity, site and mechanism of action, Central neural mechanisms in cardiovascular regulation, vol. 2, New York, Birkhauser Boston Inc. (Springer), pp. 137-152.

Joels, M., de Kloet, E.R. , Effect of corticosteroid hormones on electrical activity in rat hippocampus, J Steroid Biochem Mol Biol, vol. 40, no. 1-3, pp. 83-86.

Born, J., De Kloet, E.R., Wenz, H., Kern, W., Fehm, H.L. , Glucocorticoid and Antimineralocorticoid Effects on Human Sleep - A Role of Central Corticosteroid Receptors, Am J Physiol Endocrinol Metab, vol. 260, no. 2, pp. E183-E188.

de Kloet, E.R., Joels, M., Oitzl, M.S., Sutanto, W. , Implication of brain corticosteroid receptor diversity for the adaptation syndrome concept, Methods Achiev Exp Pathol, vol. 14, pp. 104-132.

De Kloet, E.R., Rosenfeld, P., Van Eekelen, J.A.M., Ratka, A., Joels, M., Levine, S. , Long-term effects of glucocorticoids on brain function, Peripheral signalling of the brain, Toronto, Canada, Hogrefe and Huber, pp. 225-242.

De Kloet, E.R., Joels, M. , Mineralo- and glucocorticoid receptor balance and homeostatic control, Neurosteroids and Brain Function, vol. 8, New York, Thieme Medical Publishers Inc., pp. 3-9.

Joels, M., De Kloet, E.R. , Mineralocorticoid effects on electrical activity in the rat brain, Aldosterone: fundamental aspects, vol. 215: Colloque INSERM, John Libbey Eurotext Ltd, pp. 239-248.

Sutanto, W., De Kloet, E.R. , Novel analogues of mineralocorticoids, anti-mineralocorticoids and related compounds, Current Opinion in Therapeutic Patents, vol. 1, pp. 1775-1791.

Elands, J., van Doremalen, E., Spruyt, B., De Kloet, E.R. , Oxytocin receptors in the rat hypothalamic ventromedial nucleus: a study of possible mediators of female sexual behavior, Vasopressin, vol. 208: Colloque INSERM, John Libbey Eurotext Ltd, pp. 311-319.

De Kloet, E.R., Sutanto, W., Rots, N., van Haarst, A., van den Berg, D.T., Oitzl, M.S., van Eekelen, A., Voorhuis, D. , Plasticity and function of brain corticosteroid receptors during aging, Acta Endocrinologica, vol. 125, no. 6, Suppl 1, pp. 65-72.

Iglesias, T., Verbeeck, M.A.E., De Kloet, E.R., Sutanto, W., Fuentes, J., Burbach, J.P. , Time- and region-dependent effect of adrenalectomy on neuropeptide gene expression in rat hippocampus and striatum, Molecular and Cellular Neuroscience, vol. 2, no. 6, pp. 485-490.

1990

Sijbesma, H., Schipper, J., De Kloet, E.R. , The anti-aggressive drug eltoprazine preferentially binds to 5-HT1A and 5-HT1B receptor subtypes in rat brain: sensitivity to guanine nucleotides, Eur J Pharmacol, vol. 187, no. 2, pp. 209-223.

de Kloet, E.R., Reul, J.M., Sutanto, W. , Corticosteroids and the brain, J Steroid Biochem Mol Biol, vol. 37, no. 3, pp. 387-394.

Elands, J., Resink, A., De Kloet, E.R. , Neurohypophyseal hormone receptors in the rat thymus, spleen, and lymphocytes, Endocrinology, vol. 126, no. 5, pp. 2703-2710.

Rosenfeld, P., Sutanto, W., Levine, S., de Kloet, E.R. , Ontogeny of mineralocorticoid (type 1) receptors in brain and pituitary: an in vivo autoradiographical study, Brain Res Dev Brain Res, vol. 52, no. 1-2, pp. 57-62.

Elands, J., van Woudenberg, A., Resink, A., de Kloet, E.R. , Vasopressin receptor capacity of human blood peripheral mononuclear cells is sex dependent, Brain Behav Immun, vol. 4, no. 1, pp. 30-38.

Joels, M., de Kloet, E.R. , Mineralocorticoid receptor-mediated changes in membrane properties of rat CA1 pyramidal neurons in vitro, PNAS, vol. 87, no. 12, pp. 4495-4498.

van den Berg, D.T., de Kloet, E.R., van Dijken, H.H., de Jong, W. , Differential central effects of mineralocorticoid and glucocorticoid agonists and antagonists on blood pressure, Endocrinology, vol. 126, no. 1, pp. 118-124.

Sijbesma, H., Schipper, J., de Kloet, E.R. , Eltoprazine, a drug which reduces aggressive behaviour, binds selectively to 5-HT1 receptor sites in the rat brain: an autoradiographic study, Eur J Pharmacol, vol. 177, no. 1-2, pp. 55-66.

Reul, J.M., de Kloet, E.R., van Sluijs, F.J., Rijnberk, A., Rothuizen, J. , Binding characteristics of mineralocorticoid and glucocorticoid receptors in dog brain and pituitary, Endocrinology, vol. 127, no. 2, pp. 907-915.

De Kloet, E.R. , Brain Corticosteroid Receptors and Adaptation, Psychopharmacology, vol. 101, pp. S13-S13.

De Kloet, E.R., Joels, M., Urban, I.A. , Central neurohypophyseal hormone receptors and receptor mediated cellular response, Neuropeptides: Basics and Perspectives, Amsterdam, Elsevier, pp. 105-138.

van Ree, J.M., De Kloet, E.R. , Corticotropine en Bijnierschorshormonen, Algemene Farmacotherapie: het geneesmiddel in theorie en praktijk, Houten, Bohn Stafleu van Loghum, pp. 638-659.

De Kloet, E.R. , Corticosteroid Receptor Function in the Brain, Eur J Pharmacol, vol. 183, no. 1, pp. 125-125.

Reul, J.M., Sutanto, W., van Eekelen, J.A., Rothuizen, J., de Kloet, E.R. , Central action of adrenal steroids during stress and adaptation, Adv Exp Med Biol, vol. 274, pp. 243-256.

De Kloet, E.R. , Differential effects and receptors of corticosteroids in the brain: implications for psychopathology, Neuropsychopharmacology, Berlin, Springer-Verlag, pp. 234-248.

Rothuizen, J., De Kloet, E.R., Rijnberk, A., Mol, J.A., Reul, J.M.H.M. , Deranged neuroendocrine regulation of the hypothalamic-pituitary-adrenocortical system in aging dogs, From Gene to Man: Gerontological research in The Netherlands, Rijswijk, The Netherlands, Stichting Gerontologie en Geriatrie, pp. 398-405.

Sijbesma, H., Cornelissen, J.C.H.M., De Kloet, E.R., Schipper, J. , Distribution and Characterization of 5-Ht1D Binding-Sites in the Guinea-Pig Brain - An Autoradiographic Analysis, Eur J Pharmacol, vol. 183, no. 3, pp. 1109-1110.

De Kloet, E.R., Glowinski, J., Hall, E.D., Kordon, C., Baulieu, E.E., McEwen, B.S., Feldman, S., Ramirez, V.D., Dubrovsky, B., Simmonds, M.A. , Gene-Mediated Corticosteroid Effects on Neuronal Excitability, Ciba Foundation Symposia, vol. 153, pp. 117-124.

De Kloet, E.R., Reul, J.M.H.M., Rothuizen, J. , Hypercorticism and brain corticosteroid receptor function, ACTH, Cushing's Syndrome and other Hypercortisolemic States, New York, Raven Press, pp. 21-26.

De Kloet, E.R. , Neuroendocrinology of Stress and Adaptation, Stress, Biological Rhythms and Psychiatric Disorders, Houten, The Netherlands, Medical Didactic Systems, pp. 7-11.

De Kloet, E.R., Van Eekelen, J.A.M. , Neuroendocrinology of Aging, From Gene to Man: Gerontological research in The Netherlands, Rijswijk, The Netherlands, Stichting Gerontologie en Geriatrie, pp. 381-395.

Van den Berg, D.T.W.M., De Kloet, E.R., De Jong, W. , Role of Central Corticosteroid Receptors in Cardiovascular Control, Eur J Pharmacol, vol. 183, no. 3, pp. 843-843.

Voorhuis, T.A.M., De Kloet, E.R., de Wied, D. , The vasotocin system in the canary brain, Hormones, Brain and Behaviour in Vertebrates, vol. Comp. Phys, Basel, Karger, pp. 168-179.

Voorhuis, T.A.M., Elands, J.P.M., De Kloet, E.R. , Vasotocin Target Sites in the Capsular Region Surrounding the Nucleus Robustus Archistriatalis of the Canary Brain, J Neuroendocrinol, vol. 2, no. 5, pp. 653-657.

1989

Joels, M., de Kloet, E.R. , Effects of glucocorticoids and norepinephrine on the excitability in the hippocampus, Science, vol. 245, no. 4925, pp. 1502-1505.

van den Berg, D.T., de Kloet, E.R., van Dijken, H.H., de Jong, W. , Brain corticosteroid receptors and regulation of arterial blood pressure, J Hypertens Suppl, vol. 7, no. 6, pp. S202-S203.

Ratka, A., Sutanto, W., Bloemers, M., de Kloet, E.R. , On the role of brain mineralocorticoid (type I) and glucocorticoid (type II) receptors in neuroendocrine regulation, Neuroendocrinology, vol. 50, no. 2, pp. 117-123.