2011

Datson, N.A., Polman, J.A., de Jonge, R.T., van Boheemen, P.T., van Maanen, E.M., Welten, J., McEwen, B.S., Meiland, H.C., Meijer, O.C. , Specific regulatory motifs predict glucocorticoid responsiveness of hippocampal gene expression, Endocrinology, vol. 152, no. 10, pp. 3749-3757.

Datson, N.A., Speksnijder, N., de Jong, I.E.M., Steenbergen, P.J., Vielsted Christensen, K., Potempa, K., Torleif Pedersen, J., Egebjerg, J., Kallunki, P., Nielsen, E.B., de Kloet, E.R., Didriksen, M. , Hippocampal CA1 region shows differential regulation of gene expression in mice displaying extremes in behavioral sensitization to amphetamine: relevance for psychosis susceptibility?, Psychopharmacology, vol. 217, no. 4, pp. 525-538.

2010

Sarabdjitsingh, R.A., Isenia, S., Polman, J.A., Mijalkovic, J., Lachize, S.B., Datson, N.A., de Kloet, E.R., Meijer, O.C. , Disrupted corticosterone pulsatile patterns attenuate responsiveness to glucocorticoid signaling in rat brain, Endocrinology, vol. 151, no. 3, pp. 1177-1186.

Datson, N.A., Speksnijder, N., Mayer, J.L., Steenbergen, P.J., Korobko, O., Goeman, J., de Kloet, E.R., Joels, M., Lucassen, P.J. , The transcriptional response to chronic stress and glucocorticoid receptor blockade in the hippocampal dentate gyrus, Hippocampus, pp. 1-13.

Schmidt, M.V., Trumbach, D., Weber, P., Wagner, K., Scharf, S.H., Liebl, C., Datson, N.A., Namendorf, C., Gerlach, T., Kuhne, C., Uhr, M., Deussing, J.M., Wurst, W., Binder, E.B., Holsboer, F., Muller, M.B. , Individual stress vulnerability is predicted by short-term memory and AMPA receptor subunit ratio in the hippocampus, J Neurosci, vol. 30, no. 50, pp. 16949-16958.

Van Batenburg, M.F., Li, H., Polman, J.A., Lachize, S.B., Datson, N.A., Bussemaker, H.J., Meijer, O.C. , Paired hormone response elements predict caveolin-1 as a glucocorticoid target gene, PLoS One, vol. 5, no. 1, pp. 1-9.

2009

de Kloet, E.R., Fitzsimons, C.P., Datson, N.A., Meijer, O.C., Vreugdenhil, E. , Glucocorticoid signaling and stress-related limbic susceptibility pathway: about receptors, transcription machinery and microRNA, Brain Res, vol. 1293, pp. 129-141.

Datson, N.A., Morsink, M.C., Steenbergen, P.J., Aubert, Y., Schlumbohm, C., Fuchs, E., de Kloet, E.R. , A molecular blueprint of gene expression in hippocampal subregions CA1, CA3, and DG is conserved in the brain of the common marmoset, Hippocampus, vol. 19, no. 8, pp. 739-752.

2008

Datson, N.A., Morsink, M.C., Meijer, O.C., de Kloet, E.R. , Central corticosteroid actions: Search for gene targets, Eur J Pharmacol, vol. 583, no. 2-3, pp. 272-289.

De Kloet, E.R., Datson, N.A., Revsin, Y., Champagne, D.L., Oitzl, M.S. , Brain Corticosteroid Receptor Function in Response to Psychosocial Stressors, Hormones and Social Behaviour, New York;Paris;Tokyo;, Springer, pp. 131-150.

Schmidt, M.V., Sterlermann, V., Trumbach, D., Datson, N.A., Weber, P., Holsboer, F., Muller, M.B. , Individual susceptibility to chronic stress is modulated by AMPA receptor function, Int J Neuropsychopharmacol, vol. 11, no. Suppl-S1, pp. 212-212.

Datson, N.A. , Scaling down SAGE: from miniSAGE to microSAGE, Curr Pharm Biotechnol, vol. 9, no. 5, pp. 351-361.

Schmidt, M.V., Sterlemann, V., Trumbach, D., Datson, N.A., Weber, P., Ganea, K., Liebl, C., Muller, M.B. , The genetic basis of individual vulnerability to chronic stress: role of AMPA receptors, Eur Neuropsychopharmacol, vol. 18, pp. S16-S16.

2007

Morsink, M.C., Van Gemert, N.G., Steenbergen, P.J., Joels, M., De Kloet, E.R., Datson, N.A. , Rapid glucocorticoid effects on the expression of hippocampal neurotransmission-related genes, Brain Res, vol. 1150, pp. 14-20.

Sibug, R.M., Datson, N.A., Tijssen, A.M., Morsink, M.C., de Koning, J., de Kloet, E.R., Helmerhorst, F.M. , Effects of urinary and recombinant gonadotrophins on gene expression profiles during the murine peri-implantation period, Hum Reprod, vol. 22, no. 1, pp. 75-82.

Datson, N.A., Morsink, M.C., Atanasova, S., Armstrong, V.W., Zischler, H., Schlumbohm, C., Dutilh, B.E., Huynen, M.A., Waegele, B., Ruepp, A., de Kloet, E.R., Fuchs, E. , Development of the first marmoset-specific DNA microarray (EUMAMA): a new genetic tool for large-scale expression profiling in a non-human primate, BMC Genomics, vol. 8, no. 190, pp. 1-9.

Datson, N.A., Morsink, M.C. , Expression Profiling of Stress Responsive Gene Patterns, Encyclopedia of Stress, vol. 2nd, New York, Elsevier / Academic Press, pp. 986-991.

Vos, J.B., Datson, N.A., Rabe, K.F., Hiemstra, P.S. , Exploring host-pathogen interactions at the epithelial surface: application of transcriptomics in lung biology, Am J Physiol Lung Cell Mol Physiol, vol. 292, no. 2, pp. L367-L377.

2006

Morsink, M.C., Joels, M., Sarabdjitsingh, R.A., Meijer, O.C., De Kloet, E.R., Datson, N.A. , The dynamic pattern of glucocorticoid receptor-mediated transcriptional responses in neuronal PC12 cells, J Neurochem, vol. 99, no. 4, pp. 1282-1298.

Feldker, D.E., Morsink, M.C., Veenema, A.H., Datson, N.A., Proutski, V., Lathouwers, D., de Kloet, E.R., Vreugdenhil, E. , The effect of chronic exposure to highly aggressive mice on hippocampal gene expression of non-aggressive subordinates, Brain Res, vol. 1089, no. 1, pp. 10-20.

Morsink, M.C., Steenbergen, P.J., Vos, J.B., Karst, H., Joels, M., De Kloet, E.R., Datson, N.A. , Acute activation of hippocampal glucocorticoid receptors results in different waves of gene expression throughout time, J Neuroendocrinol, vol. 18, no. 4, pp. 239-252.

Vos, J.B., Datson, N.A., van Kampen, A.H., Luyf, A.C., Verhoosel, R.M., Zeeuwen, P.L., Olthuis, D., Rabe, K.F., Schalkwijk, J., Hiemstra, P.S. , A molecular signature of epithelial host defense: comparative gene expression analysis of cultured bronchial epithelial cells and keratinocytes, BMC Genomics, vol. 7, no. 1, pp. 1-9.

2005

Vos, J.B., van Sterkenburg, M.A., Rabe, K.F., Schalkwijk, J., Hiemstra, P.S., Datson, N.A. , Transcriptional response of bronchial epithelial cells to Pseudomonas aeruginosa: identification of early mediators of host defense, Physiol Genomics, vol. 21, no. 3, pp. 324-336.

2004

Datson, N.A., Meijer, L., Steenbergen, P.J., Morsink, M.C., van der Laan, S., Meijer, O.C., de Kloet, E.R. , Expression profiling in laser-microdissected hippocampal subregions in rat brain reveals large subregion-specific differences in expression, Eur J Neurosci, vol. 20, no. 10, pp. 2541-2554.

2003

Feldker, D.E., de Kloet, E.R., Kruk, M.R., Datson, N.A. , Large-scale gene expression profiling of discrete brain regions: potential, limitations, and application in genetics of aggressive behavior, Behav Genet, vol. 33, no. 5, pp. 537-48.

Feldker, D.E., Datson, N.A., Veenema, A.H., Meulmeester, E., de Kloet, E.R., Vreugdenhil, E. , Serial analysis of gene expression predicts structural differences in hippocampus of long attack latency and short attack latency mice, Eur J Neurosci, vol. 17, no. 2, pp. 379-387.

Feldker, D.E., Datson, N.A., Veenema, A.H., Proutski, V., Lathouwers, D., De Kloet, E.R., Vreugdenhil, E. , GeneChip analysis of hippocampal gene expression profiles of short- and long-attack-latency mice: technical and biological implications, J Neurosci Res, vol. 74, no. 5, pp. 701-16.

Qin, Y., Nair, S., Karst, H., Vreugdenhil, E., Datson, N.A., Joels, M. , Gene expression changes in single dentate granule neurons after adrenalectomy of rats, Mol Brain Res, vol. 111, no. 1-2, pp. 17-23.

2002

Evans, S.J., Datson, N.A., Kabbaj, M., Thompson, R.C., Vreugdenhil, E., De Kloet, E.R., Watson, S.J., Akil, H. , Evaluation of Affymetrix Gene Chip sensitivity in rat hippocampal tissue using SAGE analysis. Serial Analysis of Gene Expression, Eur J Neurosci, vol. 16, no. 3, pp. 409-413.

2001

De Rijk, R.H., Schaaf, M.J., Turner, G., Datson, N.A., Vreugdenhil, E., Cidlowski, J., de Kloet, E.R., Emery, P., Sternberg, E.M., Detera-Wadleigh, S.D. , A human glucocorticoid receptor gene variant that increases the stability of the glucocorticoid receptor beta-isoform mRNA is associated with rheumatoid arthritis, J Rheumatol, vol. 28, no. 11, pp. 2383-8.

Vreugdenhil, E., de Kloet, E.R., Schaaf, M.J., Datson, N.A. , Genetic dissection of corticosterone receptor function in the rat hippocampus, Eur Neuropsychopharmacol, vol. 11, no. 6, pp. 423-30.

Datson, N.A., van der Perk, J., de Kloet, E.R., Vreugdenhil, E. , Identification of corticosteroid-responsive genes in rat hippocampus using serial analysis of gene expression, Eur J Neurosci, vol. 14, no. 4, pp. 675-689.

Hendriksen, H., Datson, N.A., Ghijsen, W.E., van Vliet, E.A., da Silva, F.H., Gorter, J.A., Vreugdenhil, E. , Altered hippocampal gene expression prior to the onset of spontaneous seizures in the rat post-status epilepticus model, Eur J Neurosci, vol. 14, no. 9, pp. 1475-1484.

Datson, N.A., Vreugdenhil, E. , Expression Studies, Encyclopedia of Life Sciences: John Wiley & Sons, Ltd.

Datson, N.A., van der Perk, J., de Kloet, E.R., Vreugdenhil, E. , Expression profile of 30,000 genes in rat hippocampus using SAGE, Hippocampus, vol. 11, no. 4, pp. 430-44.

Kreeft, A.J., Moen, C.J., Hofker, M.H., Frants, R.R., Vreugdenhil, E., Gijbels, M.J., Havekes, L.M., Datson, N.A. , Identification of differentially regulated genes in mildly hyperlipidemic ApoE3-Leiden mice by use of serial analysis of gene expression, Arterioscler Thromb Vasc Biol, vol. 21, no. 12, pp. 1984-1990.

1999

Datson, N.A., van der Perk-de Jong, J., van den Berg, M.P., de Kloet, E.R., Vreugdenhil, E. , MicroSAGE: a modified procedure for serial analysis of gene expression in limited amounts of tissue, Nucleic Acids Res, vol. 27, no. 5, pp. 1300-1307.

Vreugdenhil, E., Datson, N.A., Engels, B.M., de Jong, J., van Koningsbruggen, S., Schaaf, M.J., de Kloet, E.R. , Kainate-elicited seizures induce mRNA encoding a CaMK-related peptide: a putative modulator of kinase activity in rat hippocampus, J Neurobiol, vol. 39, no. 1, pp. 41-50.

1998

Vreugdenhil, E., de Jong, J., De Kloet, E.R., Datson, N.A. , Differential display, serial analysis of gem expression and corticosteroid actions in brain, Eur J Neurosci, vol. 10, pp. 265-265.

1996

Datson, N.A., Semina, E., van Staalduinen, A.A., Dauwerse, H.G., Meershoek, E.J., Heus, J.J., Frants, R.R., den Dunnen, J.T., Murray, J.C., van Ommen, G.J. , Closing in on the Rieger syndrome gene on 4q25: mapping translocation breakpoints within a 50-kb region, Am J Hum Genet, vol. 59, no. 6, pp. 1297-1305.

Semina, E.V., Reiter, R., Leysens, N.J., Alward, W.L., Small, K.W., Datson, N.A., Siegel-Bartelt, J., Bierke-Nelson, D., Bitoun, P., Zabel, B.U., Carey, J.C., Murray, J.C. , Cloning and characterization of a novel bicoid-related homeobox transcription factor gene, RIEG, involved in Rieger syndrome, Nat Genet, vol. 14, no. 4, pp. 392-399.

Semina, E.V., Datson, N.A., Leysens, N.J., Zabel, B.U., Carey, J.C., Bell, G. I, Bitoun, P., Lindgren, C., Stevenson, T., Frants, R.R., van Ommen, G.J., Murray, J.C. , Exclusion of epidermal growth factor and high-resolution physical mapping across the Rieger syndrome locus, Am J Hum Genet, vol. 59, no. 6, pp. 1288-1296.

Datson, N.A., van de Vosse, E., Dauwerse, H.G., Bout, M., van Ommen, G.J., den Dunnen, J.T. , Scanning for genes in large genomic regions: cosmid-based exon trapping of multiple exons in a single product, Nucleic Acids Res, vol. 24, no. 6, pp. 1105-1111.

1995

Van de Vosse, E., Van der Bent, P., Datson, N.A., Schuurman, E.J.M., Bergen, A.A.B., Van Ommen, G.J.B., Den Dunnen, J.T. , Construction of a transcription map in the region of the retinoschisis disease gene, Am J Hum Genet, vol. 57, no. 4, pp. 1988-1988.

Datson, N.A., Van Staalduinen, A.A., Semina, E., Meershoek, E.M., Heus, J.J., Hofker, M.H., Murray, J., Frants, R.R., Van Ommen, G.J.B., Den Dunnen, J.T. , Mapping translocation breakpoints in Rieger syndrome within a 200 KB region, Am J Hum Genet, vol. 57, no. 4, pp. 1496-1496.

Den Dunnen, J.T., Datson, N.A., Van de Vosse, E., Dauwerse, J.G., Van Ommen, G.J.B. , Scanning for genes with a cosmid-based exon trap vector, Am J Hum Genet, vol. 57, no. 4, pp. 149-149.

Cruts, M., Backhovens, H., Wang, S.Y., Van Gassen, G., Theuns, J., De Jonghe, C., Wehnert, A., De Voecht, J., De Winter, G., Cras, P., Bruyland, M., Datson, N.A., Weissenbach, J., Den Dunnen, J.T., Martin, J.J., Hendriks, L., Van Broeckhoven, C. , Molecular-genetic analysis of familial early-onset Alzheimers-disease linked to chromosome 14Q24.3, Human Molecular Genetics, vol. 4, no. 12, pp. 2363-2371.

1994

Frants, R.R., Van Deutokem, J.C.T., Rommens, J., Hewitt, J.E., Datson, N.A., Van Geel, M., Romberg, S., Van Ommen, G.J.B., Padberg, G.W., Hofker, M.H., Wijmenga, C. , Isolation of cDNA's from the facioscapulohumeral muscular-dystrophy region, Cytogenetics and Cell Genetics, vol. 66, no. 4, pp. 232-233.

Datson, N.A., Duyk, G.M., van Ommen, G.J., den Dunnen, J.T. , Specific isolation of 3'-terminal exons of human genes by exon trapping, Nucleic Acids Res, vol. 22, no. 20, pp. 4148-4153.

De Rooij, K.E., de Koning Gans, P.A.M., Datson, N.A., Slingsby, J.H., Folman, C., Skraastad, M. I, Den Dunnen, J.T., Van Ommen, G.J.B. , Searching for genes in a 450 KB cosmid contig near the Huntingtons-disease gene, Cytogenetics and Cell Genetics, vol. 66, no. 4, pp. 233-233.

1993

Frants, R.R., Van Deutekom, J.C.T., Rommens, J., Hewitt, J.E., Datson, N.A., Van Geel, M., Romberg, S., Van Ommen, G.J.B., Padberg, G.W., Hofker, M.H., Wijmenga, C. , Isolation of cDNA's from the facioscapulohumeral muscular-dystrophy region, Am J Hum Genet, vol. 53, no. 3, pp. 54-54.

1991

Snell, R.G., Holloway, T.L., Datson, N.A., Lazarou, L.P., Harper, P.S., Wasmuth, J.J., Shaw, D.J. , Linkage disequilibrium and the huntingtons-disease gene, Cytogenetics and Cell Genetics, vol. 58, no. 3-4, pp. 1890-1890.

Snell, R.G., Sandkuijl, L.A., Lazarou, L.P., Holloway, T.L., Datson, N.A., Youngman, S., Altherr, M.R., Harper, P.S., Shaw, D.J. , The refined location of the Huntingtons-disease gene by a new mapping technique, association mapping - and isolation of a cDNA in that region, Am J Hum Genet, vol. 49, no. 4, pp. 371-371.

1989

Datson, N.A., van der Saag, P.T., Oostra, B.A. , RFLP for the human retinoic acid receptor gene RAR-beta, Nucleic Acids Res, vol. 17, no. 21, pp. 8897.

Nicole currently supervises the following students:

• Yves Aubert
• Annelies Polman
• Niels Speksnijder